Cargando…

Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma

BACKGROUND: Intractable nasopharyngeal hemorrhage is a severe complication with high mortality rate in patients with radiation therapy (RT) for nasopharyngeal carcinoma (NPC) that requires emergency treatment. Quite a few of them combine with tumor recurrence. Treatment planning for these patients i...

Descripción completa

Detalles Bibliográficos
Autores principales: Duan, Bao‐Feng, Chen, Hua‐Ying, Zheng, Xue‐Mei, He, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575488/
https://www.ncbi.nlm.nih.gov/pubmed/35861475
http://dx.doi.org/10.1002/cnr2.1671
_version_ 1784811326276632576
author Duan, Bao‐Feng
Chen, Hua‐Ying
Zheng, Xue‐Mei
He, Qing
author_facet Duan, Bao‐Feng
Chen, Hua‐Ying
Zheng, Xue‐Mei
He, Qing
author_sort Duan, Bao‐Feng
collection PubMed
description BACKGROUND: Intractable nasopharyngeal hemorrhage is a severe complication with high mortality rate in patients with radiation therapy (RT) for nasopharyngeal carcinoma (NPC) that requires emergency treatment. Quite a few of them combine with tumor recurrence. Treatment planning for these patients is extremely difficult for oncologists, and effective treatments are lacking. CASE: A 42‐year‐old man had a history of recurrent NPC that was treated with 2 cycles of chemoradiotherapies from 2017 to 2019. Five months after the second round of chemoradiotherapy, an episode of massive nasal bleeding occurred. As positron emission tomography (PET) scan revealed tumor recurrence in the left wall of nasopharynx, superselective embolization and subsequent intra‐arterial infusion (IA, 4 times of cisplatin 60 mg + fluorouracil 1.0 g) were performed to stop bleeding and achieve tumor control. To date, the disease‐free survival time has been over 1 year. No tumor recurrence or rebleeding is found except for alopecia on the left side. CONCLUSIONS: Interventional radiology is important and effective in the treatment of recurrent NPC for both massive nasal bleeding and tumor control. However, the unique complication of unilateral alopecia should not be ignored.
format Online
Article
Text
id pubmed-9575488
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-95754882022-10-18 Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma Duan, Bao‐Feng Chen, Hua‐Ying Zheng, Xue‐Mei He, Qing Cancer Rep (Hoboken) Case Reports BACKGROUND: Intractable nasopharyngeal hemorrhage is a severe complication with high mortality rate in patients with radiation therapy (RT) for nasopharyngeal carcinoma (NPC) that requires emergency treatment. Quite a few of them combine with tumor recurrence. Treatment planning for these patients is extremely difficult for oncologists, and effective treatments are lacking. CASE: A 42‐year‐old man had a history of recurrent NPC that was treated with 2 cycles of chemoradiotherapies from 2017 to 2019. Five months after the second round of chemoradiotherapy, an episode of massive nasal bleeding occurred. As positron emission tomography (PET) scan revealed tumor recurrence in the left wall of nasopharynx, superselective embolization and subsequent intra‐arterial infusion (IA, 4 times of cisplatin 60 mg + fluorouracil 1.0 g) were performed to stop bleeding and achieve tumor control. To date, the disease‐free survival time has been over 1 year. No tumor recurrence or rebleeding is found except for alopecia on the left side. CONCLUSIONS: Interventional radiology is important and effective in the treatment of recurrent NPC for both massive nasal bleeding and tumor control. However, the unique complication of unilateral alopecia should not be ignored. John Wiley and Sons Inc. 2022-07-21 /pmc/articles/PMC9575488/ /pubmed/35861475 http://dx.doi.org/10.1002/cnr2.1671 Text en © 2022 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Duan, Bao‐Feng
Chen, Hua‐Ying
Zheng, Xue‐Mei
He, Qing
Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma
title Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma
title_full Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma
title_fullStr Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma
title_full_unstemmed Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma
title_short Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma
title_sort acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575488/
https://www.ncbi.nlm.nih.gov/pubmed/35861475
http://dx.doi.org/10.1002/cnr2.1671
work_keys_str_mv AT duanbaofeng acquiredunilateralalopeciaafterarterialinfusionchemotherapyinarecurrentnasopharyngealcarcinoma
AT chenhuaying acquiredunilateralalopeciaafterarterialinfusionchemotherapyinarecurrentnasopharyngealcarcinoma
AT zhengxuemei acquiredunilateralalopeciaafterarterialinfusionchemotherapyinarecurrentnasopharyngealcarcinoma
AT heqing acquiredunilateralalopeciaafterarterialinfusionchemotherapyinarecurrentnasopharyngealcarcinoma