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Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma
BACKGROUND: Intractable nasopharyngeal hemorrhage is a severe complication with high mortality rate in patients with radiation therapy (RT) for nasopharyngeal carcinoma (NPC) that requires emergency treatment. Quite a few of them combine with tumor recurrence. Treatment planning for these patients i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575488/ https://www.ncbi.nlm.nih.gov/pubmed/35861475 http://dx.doi.org/10.1002/cnr2.1671 |
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author | Duan, Bao‐Feng Chen, Hua‐Ying Zheng, Xue‐Mei He, Qing |
author_facet | Duan, Bao‐Feng Chen, Hua‐Ying Zheng, Xue‐Mei He, Qing |
author_sort | Duan, Bao‐Feng |
collection | PubMed |
description | BACKGROUND: Intractable nasopharyngeal hemorrhage is a severe complication with high mortality rate in patients with radiation therapy (RT) for nasopharyngeal carcinoma (NPC) that requires emergency treatment. Quite a few of them combine with tumor recurrence. Treatment planning for these patients is extremely difficult for oncologists, and effective treatments are lacking. CASE: A 42‐year‐old man had a history of recurrent NPC that was treated with 2 cycles of chemoradiotherapies from 2017 to 2019. Five months after the second round of chemoradiotherapy, an episode of massive nasal bleeding occurred. As positron emission tomography (PET) scan revealed tumor recurrence in the left wall of nasopharynx, superselective embolization and subsequent intra‐arterial infusion (IA, 4 times of cisplatin 60 mg + fluorouracil 1.0 g) were performed to stop bleeding and achieve tumor control. To date, the disease‐free survival time has been over 1 year. No tumor recurrence or rebleeding is found except for alopecia on the left side. CONCLUSIONS: Interventional radiology is important and effective in the treatment of recurrent NPC for both massive nasal bleeding and tumor control. However, the unique complication of unilateral alopecia should not be ignored. |
format | Online Article Text |
id | pubmed-9575488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95754882022-10-18 Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma Duan, Bao‐Feng Chen, Hua‐Ying Zheng, Xue‐Mei He, Qing Cancer Rep (Hoboken) Case Reports BACKGROUND: Intractable nasopharyngeal hemorrhage is a severe complication with high mortality rate in patients with radiation therapy (RT) for nasopharyngeal carcinoma (NPC) that requires emergency treatment. Quite a few of them combine with tumor recurrence. Treatment planning for these patients is extremely difficult for oncologists, and effective treatments are lacking. CASE: A 42‐year‐old man had a history of recurrent NPC that was treated with 2 cycles of chemoradiotherapies from 2017 to 2019. Five months after the second round of chemoradiotherapy, an episode of massive nasal bleeding occurred. As positron emission tomography (PET) scan revealed tumor recurrence in the left wall of nasopharynx, superselective embolization and subsequent intra‐arterial infusion (IA, 4 times of cisplatin 60 mg + fluorouracil 1.0 g) were performed to stop bleeding and achieve tumor control. To date, the disease‐free survival time has been over 1 year. No tumor recurrence or rebleeding is found except for alopecia on the left side. CONCLUSIONS: Interventional radiology is important and effective in the treatment of recurrent NPC for both massive nasal bleeding and tumor control. However, the unique complication of unilateral alopecia should not be ignored. John Wiley and Sons Inc. 2022-07-21 /pmc/articles/PMC9575488/ /pubmed/35861475 http://dx.doi.org/10.1002/cnr2.1671 Text en © 2022 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Duan, Bao‐Feng Chen, Hua‐Ying Zheng, Xue‐Mei He, Qing Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
title | Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
title_full | Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
title_fullStr | Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
title_full_unstemmed | Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
title_short | Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
title_sort | acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575488/ https://www.ncbi.nlm.nih.gov/pubmed/35861475 http://dx.doi.org/10.1002/cnr2.1671 |
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