Co‐occurrence of JAK2 V617F‐mutated essential thrombocythemia and chronic lymphocytic leukemia harboring der(8;17)(q10;q10)

BACKGROUND AND CASE: We herein present a case of the co‐occurrence of JAK2‐mutated essential thrombocythemia (ET) with chronic lymphocytic leukemia (CLL) harboring the recurrent and rare whole‐arm translocation, der(8;17)(q10;q10). The co‐existence of lymphoproliferative neoplasms and myeloprolifera...

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Autores principales: Manabe, Masahiro, Tanizawa, Nao, Nanno, Satoru, Hagiwara, Yuuji, Asada, Reiko, Koh, Ki‐Ryang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575505/
https://www.ncbi.nlm.nih.gov/pubmed/35715969
http://dx.doi.org/10.1002/cnr2.1658
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author Manabe, Masahiro
Tanizawa, Nao
Nanno, Satoru
Hagiwara, Yuuji
Asada, Reiko
Koh, Ki‐Ryang
author_facet Manabe, Masahiro
Tanizawa, Nao
Nanno, Satoru
Hagiwara, Yuuji
Asada, Reiko
Koh, Ki‐Ryang
author_sort Manabe, Masahiro
collection PubMed
description BACKGROUND AND CASE: We herein present a case of the co‐occurrence of JAK2‐mutated essential thrombocythemia (ET) with chronic lymphocytic leukemia (CLL) harboring the recurrent and rare whole‐arm translocation, der(8;17)(q10;q10). The co‐existence of lymphoproliferative neoplasms and myeloproliferative neoplasms is suggested to be a rare event. Under this condition, the lymphoproliferative disorder presents a clinically indolent course with a low‐risk biological profile. However, the present case showed aggressive disease progression, reflecting a poor prognostic factor; that is, the loss of 17p caused by the whole‐arm der(8;17)(q10;q10) translocation. CONCLUSION: The present case report emphasizes the importance of considering the involvement of a genetically poor prognostic factor, regardless of the co‐occurrence of CLL and ET.
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spelling pubmed-95755052022-10-18 Co‐occurrence of JAK2 V617F‐mutated essential thrombocythemia and chronic lymphocytic leukemia harboring der(8;17)(q10;q10) Manabe, Masahiro Tanizawa, Nao Nanno, Satoru Hagiwara, Yuuji Asada, Reiko Koh, Ki‐Ryang Cancer Rep (Hoboken) Case Reports BACKGROUND AND CASE: We herein present a case of the co‐occurrence of JAK2‐mutated essential thrombocythemia (ET) with chronic lymphocytic leukemia (CLL) harboring the recurrent and rare whole‐arm translocation, der(8;17)(q10;q10). The co‐existence of lymphoproliferative neoplasms and myeloproliferative neoplasms is suggested to be a rare event. Under this condition, the lymphoproliferative disorder presents a clinically indolent course with a low‐risk biological profile. However, the present case showed aggressive disease progression, reflecting a poor prognostic factor; that is, the loss of 17p caused by the whole‐arm der(8;17)(q10;q10) translocation. CONCLUSION: The present case report emphasizes the importance of considering the involvement of a genetically poor prognostic factor, regardless of the co‐occurrence of CLL and ET. John Wiley and Sons Inc. 2022-06-17 /pmc/articles/PMC9575505/ /pubmed/35715969 http://dx.doi.org/10.1002/cnr2.1658 Text en © 2022 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Manabe, Masahiro
Tanizawa, Nao
Nanno, Satoru
Hagiwara, Yuuji
Asada, Reiko
Koh, Ki‐Ryang
Co‐occurrence of JAK2 V617F‐mutated essential thrombocythemia and chronic lymphocytic leukemia harboring der(8;17)(q10;q10)
title Co‐occurrence of JAK2 V617F‐mutated essential thrombocythemia and chronic lymphocytic leukemia harboring der(8;17)(q10;q10)
title_full Co‐occurrence of JAK2 V617F‐mutated essential thrombocythemia and chronic lymphocytic leukemia harboring der(8;17)(q10;q10)
title_fullStr Co‐occurrence of JAK2 V617F‐mutated essential thrombocythemia and chronic lymphocytic leukemia harboring der(8;17)(q10;q10)
title_full_unstemmed Co‐occurrence of JAK2 V617F‐mutated essential thrombocythemia and chronic lymphocytic leukemia harboring der(8;17)(q10;q10)
title_short Co‐occurrence of JAK2 V617F‐mutated essential thrombocythemia and chronic lymphocytic leukemia harboring der(8;17)(q10;q10)
title_sort co‐occurrence of jak2 v617f‐mutated essential thrombocythemia and chronic lymphocytic leukemia harboring der(8;17)(q10;q10)
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575505/
https://www.ncbi.nlm.nih.gov/pubmed/35715969
http://dx.doi.org/10.1002/cnr2.1658
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