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Blood products and liver transplantation: A strategy to balance optimal preparation with effective blood stewardship

BACKGROUND: Unanticipated transfusion requirements during liver transplantation can delay lifesaving intraoperative resuscitation and strain blood bank resources. Risk‐stratified preoperative blood preparation can mitigate these deleterious outcomes. STUDY DESIGN AND METHODS: A two‐tiered blood prep...

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Autores principales: Little, Christopher J., Leverson, Glen E., Hammel, Laura L., Connor, Joseph P., Al‐Adra, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575510/
https://www.ncbi.nlm.nih.gov/pubmed/35986654
http://dx.doi.org/10.1111/trf.17074
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author Little, Christopher J.
Leverson, Glen E.
Hammel, Laura L.
Connor, Joseph P.
Al‐Adra, David P.
author_facet Little, Christopher J.
Leverson, Glen E.
Hammel, Laura L.
Connor, Joseph P.
Al‐Adra, David P.
author_sort Little, Christopher J.
collection PubMed
description BACKGROUND: Unanticipated transfusion requirements during liver transplantation can delay lifesaving intraoperative resuscitation and strain blood bank resources. Risk‐stratified preoperative blood preparation can mitigate these deleterious outcomes. STUDY DESIGN AND METHODS: A two‐tiered blood preparation protocol for liver transplantation was retrospectively evaluated. Eleven binary variables served as criteria for high‐risk (HR) allocation. Primary outcomes included red blood cell (RBC), plasma (FFP), and platelet (Plt) utilization. Secondary outcomes included product under‐ and overpreparation. Contingency tables for transfusion requirements above the population means were generated using 15 clinical variables. Modified protocols were developed and retrospectively optimized using the study population. RESULTS: Of 225 recipients, 102 received HR preoperative orders, which correlated to higher intraoperative transfusion requirements. However, univariate analysis identified only two statistical risk factors per product: Hgb ≤7.8 g/dl (p < .001) and MELD ≥38 (p = .035) for RBCs, Hgb ≤7.8 g/dl (p = .002) and acute alcoholic hepatitis (p = 0.015) for FFP, and Hgb ≤7.8 g/dl (p = .001) and normothermic liver preservation (p = .037) for Plts. Based on these findings, we developed modified protocols for individual products, which were evaluated retrospectively for their effectiveness at reducing under‐preparatory events while limiting product overpreparation. Cohort statistics were used to define the preparation strategy for each protocol. Retrospective comparative analysis demonstrated the superiority of the modified protocols by improving the under‐preparation rate from 24% to <10% for each product, which required a 1.56‐fold and 1.44‐fold increase in RBC and FFP overpreparation, respectively. Importantly, there was no difference in Plt overpreparation. DISCUSSION: We report translatable data‐driven blood bank preparation protocols for liver transplantation.
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spelling pubmed-95755102023-01-03 Blood products and liver transplantation: A strategy to balance optimal preparation with effective blood stewardship Little, Christopher J. Leverson, Glen E. Hammel, Laura L. Connor, Joseph P. Al‐Adra, David P. Transfusion Transfusion Service BACKGROUND: Unanticipated transfusion requirements during liver transplantation can delay lifesaving intraoperative resuscitation and strain blood bank resources. Risk‐stratified preoperative blood preparation can mitigate these deleterious outcomes. STUDY DESIGN AND METHODS: A two‐tiered blood preparation protocol for liver transplantation was retrospectively evaluated. Eleven binary variables served as criteria for high‐risk (HR) allocation. Primary outcomes included red blood cell (RBC), plasma (FFP), and platelet (Plt) utilization. Secondary outcomes included product under‐ and overpreparation. Contingency tables for transfusion requirements above the population means were generated using 15 clinical variables. Modified protocols were developed and retrospectively optimized using the study population. RESULTS: Of 225 recipients, 102 received HR preoperative orders, which correlated to higher intraoperative transfusion requirements. However, univariate analysis identified only two statistical risk factors per product: Hgb ≤7.8 g/dl (p < .001) and MELD ≥38 (p = .035) for RBCs, Hgb ≤7.8 g/dl (p = .002) and acute alcoholic hepatitis (p = 0.015) for FFP, and Hgb ≤7.8 g/dl (p = .001) and normothermic liver preservation (p = .037) for Plts. Based on these findings, we developed modified protocols for individual products, which were evaluated retrospectively for their effectiveness at reducing under‐preparatory events while limiting product overpreparation. Cohort statistics were used to define the preparation strategy for each protocol. Retrospective comparative analysis demonstrated the superiority of the modified protocols by improving the under‐preparation rate from 24% to <10% for each product, which required a 1.56‐fold and 1.44‐fold increase in RBC and FFP overpreparation, respectively. Importantly, there was no difference in Plt overpreparation. DISCUSSION: We report translatable data‐driven blood bank preparation protocols for liver transplantation. John Wiley & Sons, Inc. 2022-08-20 2022-10 /pmc/articles/PMC9575510/ /pubmed/35986654 http://dx.doi.org/10.1111/trf.17074 Text en © 2022 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Transfusion Service
Little, Christopher J.
Leverson, Glen E.
Hammel, Laura L.
Connor, Joseph P.
Al‐Adra, David P.
Blood products and liver transplantation: A strategy to balance optimal preparation with effective blood stewardship
title Blood products and liver transplantation: A strategy to balance optimal preparation with effective blood stewardship
title_full Blood products and liver transplantation: A strategy to balance optimal preparation with effective blood stewardship
title_fullStr Blood products and liver transplantation: A strategy to balance optimal preparation with effective blood stewardship
title_full_unstemmed Blood products and liver transplantation: A strategy to balance optimal preparation with effective blood stewardship
title_short Blood products and liver transplantation: A strategy to balance optimal preparation with effective blood stewardship
title_sort blood products and liver transplantation: a strategy to balance optimal preparation with effective blood stewardship
topic Transfusion Service
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575510/
https://www.ncbi.nlm.nih.gov/pubmed/35986654
http://dx.doi.org/10.1111/trf.17074
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