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Advancements in antimicrobial nanoscale materials and self-assembling systems
Antimicrobial resistance is directly responsible for more deaths per year than either HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at least $100 trillion between 2014 and 2050. Already heralded as one of the greatest threats to human health, the onset of th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575517/ https://www.ncbi.nlm.nih.gov/pubmed/36190355 http://dx.doi.org/10.1039/d1cs00915j |
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author | Doolan, Jack A. Williams, George T. Hilton, Kira L. F. Chaudhari, Rajas Fossey, John S. Goult, Benjamin T. Hiscock, Jennifer R. |
author_facet | Doolan, Jack A. Williams, George T. Hilton, Kira L. F. Chaudhari, Rajas Fossey, John S. Goult, Benjamin T. Hiscock, Jennifer R. |
author_sort | Doolan, Jack A. |
collection | PubMed |
description | Antimicrobial resistance is directly responsible for more deaths per year than either HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at least $100 trillion between 2014 and 2050. Already heralded as one of the greatest threats to human health, the onset of the coronavirus pandemic has accelerated the prevalence of antimicrobial resistant bacterial infections due to factors including increased global antibiotic/antimicrobial use. Thus an urgent need for novel therapeutics to combat what some have termed the ‘silent pandemic’ is evident. This review acts as a repository of research and an overview of the novel therapeutic strategies being developed to overcome antimicrobial resistance, with a focus on self-assembling systems and nanoscale materials. The fundamental mechanisms of action, as well as the key advantages and disadvantages of each system are discussed, and attention is drawn to key examples within each field. As a result, this review provides a guide to the further design and development of antimicrobial systems, and outlines the interdisciplinary techniques required to translate this fundamental research towards the clinic. |
format | Online Article Text |
id | pubmed-9575517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-95755172022-10-31 Advancements in antimicrobial nanoscale materials and self-assembling systems Doolan, Jack A. Williams, George T. Hilton, Kira L. F. Chaudhari, Rajas Fossey, John S. Goult, Benjamin T. Hiscock, Jennifer R. Chem Soc Rev Chemistry Antimicrobial resistance is directly responsible for more deaths per year than either HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at least $100 trillion between 2014 and 2050. Already heralded as one of the greatest threats to human health, the onset of the coronavirus pandemic has accelerated the prevalence of antimicrobial resistant bacterial infections due to factors including increased global antibiotic/antimicrobial use. Thus an urgent need for novel therapeutics to combat what some have termed the ‘silent pandemic’ is evident. This review acts as a repository of research and an overview of the novel therapeutic strategies being developed to overcome antimicrobial resistance, with a focus on self-assembling systems and nanoscale materials. The fundamental mechanisms of action, as well as the key advantages and disadvantages of each system are discussed, and attention is drawn to key examples within each field. As a result, this review provides a guide to the further design and development of antimicrobial systems, and outlines the interdisciplinary techniques required to translate this fundamental research towards the clinic. The Royal Society of Chemistry 2022-10-03 /pmc/articles/PMC9575517/ /pubmed/36190355 http://dx.doi.org/10.1039/d1cs00915j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Doolan, Jack A. Williams, George T. Hilton, Kira L. F. Chaudhari, Rajas Fossey, John S. Goult, Benjamin T. Hiscock, Jennifer R. Advancements in antimicrobial nanoscale materials and self-assembling systems |
title | Advancements in antimicrobial nanoscale materials and self-assembling systems |
title_full | Advancements in antimicrobial nanoscale materials and self-assembling systems |
title_fullStr | Advancements in antimicrobial nanoscale materials and self-assembling systems |
title_full_unstemmed | Advancements in antimicrobial nanoscale materials and self-assembling systems |
title_short | Advancements in antimicrobial nanoscale materials and self-assembling systems |
title_sort | advancements in antimicrobial nanoscale materials and self-assembling systems |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575517/ https://www.ncbi.nlm.nih.gov/pubmed/36190355 http://dx.doi.org/10.1039/d1cs00915j |
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