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Deficiency of MST1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by IL-10

Changes in the function of peritoneal macrophages contribute to the homeostasis of the peritoneal immune microenvironment in endometriosis. The mechanism by which ectopic tissues escape phagocytic clearance by macrophages to achieve ectopic colonization and proliferation is unknown. The expression o...

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Autores principales: Huang, Yufei, Yan, Shumin, Dong, Xiaoyu, Jiao, Xue, Wang, Shuang, Li, Dong, Wang, Guoyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575673/
https://www.ncbi.nlm.nih.gov/pubmed/36263059
http://dx.doi.org/10.3389/fimmu.2022.993788
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author Huang, Yufei
Yan, Shumin
Dong, Xiaoyu
Jiao, Xue
Wang, Shuang
Li, Dong
Wang, Guoyun
author_facet Huang, Yufei
Yan, Shumin
Dong, Xiaoyu
Jiao, Xue
Wang, Shuang
Li, Dong
Wang, Guoyun
author_sort Huang, Yufei
collection PubMed
description Changes in the function of peritoneal macrophages contribute to the homeostasis of the peritoneal immune microenvironment in endometriosis. The mechanism by which ectopic tissues escape phagocytic clearance by macrophages to achieve ectopic colonization and proliferation is unknown. The expression of CD163 in peritoneal macrophages in patients with endometriosis is increased, with the overexpression of MAPK, which can promote the M2-type polarization of macrophages and reduce their ability to phagocytose ectopic endometrial cells. As an upstream regulator of MAPK, MST1 expression is deficient in peritoneal macrophages of patients with endometriosis. This process is regulated by miR-887-5p, a noncoding RNA targeting MST1. Moreover, MST1-knockout macrophages secrete anti-inflammatory factor IL-10, which promotes autophagy of ectopic endometrial stromal cells. These results suggest that MST1 deficient macrophages may accelerate the autophagy of ectopic endometrium via IL-10 which was regulated by miR-887-5p.
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spelling pubmed-95756732022-10-18 Deficiency of MST1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by IL-10 Huang, Yufei Yan, Shumin Dong, Xiaoyu Jiao, Xue Wang, Shuang Li, Dong Wang, Guoyun Front Immunol Immunology Changes in the function of peritoneal macrophages contribute to the homeostasis of the peritoneal immune microenvironment in endometriosis. The mechanism by which ectopic tissues escape phagocytic clearance by macrophages to achieve ectopic colonization and proliferation is unknown. The expression of CD163 in peritoneal macrophages in patients with endometriosis is increased, with the overexpression of MAPK, which can promote the M2-type polarization of macrophages and reduce their ability to phagocytose ectopic endometrial cells. As an upstream regulator of MAPK, MST1 expression is deficient in peritoneal macrophages of patients with endometriosis. This process is regulated by miR-887-5p, a noncoding RNA targeting MST1. Moreover, MST1-knockout macrophages secrete anti-inflammatory factor IL-10, which promotes autophagy of ectopic endometrial stromal cells. These results suggest that MST1 deficient macrophages may accelerate the autophagy of ectopic endometrium via IL-10 which was regulated by miR-887-5p. Frontiers Media S.A. 2022-10-03 /pmc/articles/PMC9575673/ /pubmed/36263059 http://dx.doi.org/10.3389/fimmu.2022.993788 Text en Copyright © 2022 Huang, Yan, Dong, Jiao, Wang, Li and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Yufei
Yan, Shumin
Dong, Xiaoyu
Jiao, Xue
Wang, Shuang
Li, Dong
Wang, Guoyun
Deficiency of MST1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by IL-10
title Deficiency of MST1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by IL-10
title_full Deficiency of MST1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by IL-10
title_fullStr Deficiency of MST1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by IL-10
title_full_unstemmed Deficiency of MST1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by IL-10
title_short Deficiency of MST1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by IL-10
title_sort deficiency of mst1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by il-10
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575673/
https://www.ncbi.nlm.nih.gov/pubmed/36263059
http://dx.doi.org/10.3389/fimmu.2022.993788
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