Developmentally regulated alternate 3′ end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineage

Alternative polyadenylation (APA) generates transcript isoforms that differ in the position of the 3′ cleavage site, resulting in the production of mRNA isoforms with different length 3′ UTRs. Although widespread, the role of APA in the biology of cells, tissues, and organisms has been controversial...

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Detalles Bibliográficos
Autores principales: Berry, Cameron W., Olivares, Gonzalo H., Gallicchio, Lorenzo, Ramaswami, Gokul, Glavic, Alvaro, Olguín, Patricio, Li, Jin Billy, Fuller, Margaret T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575692/
https://www.ncbi.nlm.nih.gov/pubmed/36175033
http://dx.doi.org/10.1101/gad.349689.122

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