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Comprehensive exploration of the expression and prognostic value of AQPs in clear cell renal cell carcinoma
Aquaporins (AQPs) are a family of membrane water channels that facilitate the passive transport of water across the plasma membrane of cells in response to osmotic gradients created by the active transport of solutes. Water-selective AQPs are involved in tumor angiogenesis, invasion, metastasis and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575724/ https://www.ncbi.nlm.nih.gov/pubmed/36254092 http://dx.doi.org/10.1097/MD.0000000000029344 |
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author | Wang, Huanrui Zhang, Weiyu Ding, Zehua Xu, Tao Zhang, Xiaopeng Xu, Kexin |
author_facet | Wang, Huanrui Zhang, Weiyu Ding, Zehua Xu, Tao Zhang, Xiaopeng Xu, Kexin |
author_sort | Wang, Huanrui |
collection | PubMed |
description | Aquaporins (AQPs) are a family of membrane water channels that facilitate the passive transport of water across the plasma membrane of cells in response to osmotic gradients created by the active transport of solutes. Water-selective AQPs are involved in tumor angiogenesis, invasion, metastasis and growth. However, the polytype expression patterns and prognostic values of eleven AQPs in clear cell Renal Cell Cancer (ccRCC) have yet to be filled. We preliminarily investigated the transcriptional expression, survival data and immune infiltration of AQPs in patients with renal cell cancer via the Oncomine database, Kaplan–Meier Plotter, UALCAN cancer database, and cBioPortal databases. The ethical approval was waived by the local ethics committee of Peking University People's Hospital for the natural feature of mine into databases. The mRNA expression of AQP1/2/3/4/5/6/7/11 was significantly decreased in ccRCC patients. Meanwhile, MIP and AQP1/2/4/6/7/8/9/11 are notably related to the clinical stage or pathological grade of ccRCC. Lower levels of AQP1/3/4/5/7/10 expression were related to worse overall survival (OS) in patients diagnosed with ccRCC. The AQP mutation rate was 25% in ccRCC patients, but genetic alterations in AQPs were unlikely to be associated with OS and disease free survival in ccRCC patients. In addition, the expression of AQP1, AQP3, AQP4 and AQP10 was positively correlated with immune cells, and the expression of AQP6, AQP7 and AQP11 was negatively correlated with immune cells. AQP9 had a strong and significantly positive correlation with multiple immune cells. Abnormal expression of AQPs in ccRCC indicated the prognosis and immunomodulatory state of ccRCC. Further study needs to be performed to explore AQPs as new biomarkers for ccRCC. |
format | Online Article Text |
id | pubmed-9575724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-95757242022-10-17 Comprehensive exploration of the expression and prognostic value of AQPs in clear cell renal cell carcinoma Wang, Huanrui Zhang, Weiyu Ding, Zehua Xu, Tao Zhang, Xiaopeng Xu, Kexin Medicine (Baltimore) 5700 Aquaporins (AQPs) are a family of membrane water channels that facilitate the passive transport of water across the plasma membrane of cells in response to osmotic gradients created by the active transport of solutes. Water-selective AQPs are involved in tumor angiogenesis, invasion, metastasis and growth. However, the polytype expression patterns and prognostic values of eleven AQPs in clear cell Renal Cell Cancer (ccRCC) have yet to be filled. We preliminarily investigated the transcriptional expression, survival data and immune infiltration of AQPs in patients with renal cell cancer via the Oncomine database, Kaplan–Meier Plotter, UALCAN cancer database, and cBioPortal databases. The ethical approval was waived by the local ethics committee of Peking University People's Hospital for the natural feature of mine into databases. The mRNA expression of AQP1/2/3/4/5/6/7/11 was significantly decreased in ccRCC patients. Meanwhile, MIP and AQP1/2/4/6/7/8/9/11 are notably related to the clinical stage or pathological grade of ccRCC. Lower levels of AQP1/3/4/5/7/10 expression were related to worse overall survival (OS) in patients diagnosed with ccRCC. The AQP mutation rate was 25% in ccRCC patients, but genetic alterations in AQPs were unlikely to be associated with OS and disease free survival in ccRCC patients. In addition, the expression of AQP1, AQP3, AQP4 and AQP10 was positively correlated with immune cells, and the expression of AQP6, AQP7 and AQP11 was negatively correlated with immune cells. AQP9 had a strong and significantly positive correlation with multiple immune cells. Abnormal expression of AQPs in ccRCC indicated the prognosis and immunomodulatory state of ccRCC. Further study needs to be performed to explore AQPs as new biomarkers for ccRCC. Lippincott Williams & Wilkins 2022-10-14 /pmc/articles/PMC9575724/ /pubmed/36254092 http://dx.doi.org/10.1097/MD.0000000000029344 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 5700 Wang, Huanrui Zhang, Weiyu Ding, Zehua Xu, Tao Zhang, Xiaopeng Xu, Kexin Comprehensive exploration of the expression and prognostic value of AQPs in clear cell renal cell carcinoma |
title | Comprehensive exploration of the expression and prognostic value of AQPs in clear cell renal cell carcinoma |
title_full | Comprehensive exploration of the expression and prognostic value of AQPs in clear cell renal cell carcinoma |
title_fullStr | Comprehensive exploration of the expression and prognostic value of AQPs in clear cell renal cell carcinoma |
title_full_unstemmed | Comprehensive exploration of the expression and prognostic value of AQPs in clear cell renal cell carcinoma |
title_short | Comprehensive exploration of the expression and prognostic value of AQPs in clear cell renal cell carcinoma |
title_sort | comprehensive exploration of the expression and prognostic value of aqps in clear cell renal cell carcinoma |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575724/ https://www.ncbi.nlm.nih.gov/pubmed/36254092 http://dx.doi.org/10.1097/MD.0000000000029344 |
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