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Correlation between ERα gene polymorphism and multiple sclerosis and neuromyelitis optica

To study the polymorphism distribution of estrogen receptor (ER) α gene and the correlation between different types of polymorphism in multiple sclerosis (MS) and neuromyelitis optica (NMO) patients. METHODS: Forty-six cases of MS and NMO diagnosed from June 2018 to December 2019 were collected. Per...

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Autores principales: Xing, Weifang, Hong, Mingfan, Wei, Zhisheng, Zhang, Wensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575784/
https://www.ncbi.nlm.nih.gov/pubmed/36254093
http://dx.doi.org/10.1097/MD.0000000000031126
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author Xing, Weifang
Hong, Mingfan
Wei, Zhisheng
Zhang, Wensheng
author_facet Xing, Weifang
Hong, Mingfan
Wei, Zhisheng
Zhang, Wensheng
author_sort Xing, Weifang
collection PubMed
description To study the polymorphism distribution of estrogen receptor (ER) α gene and the correlation between different types of polymorphism in multiple sclerosis (MS) and neuromyelitis optica (NMO) patients. METHODS: Forty-six cases of MS and NMO diagnosed from June 2018 to December 2019 were collected. Peripheral venous blood samples were collected. The patient’s gender, age of onset, course of disease, and other clinical data were recorded. Fifty-eight healthy volunteers of the same age and sex were selected. By means of Pvu II and Xba I restriction fragment length polymorphism enzyme recognition sites of ER α gene, polymerase chain reaction-restriction fragment length polymorphism analysis was conducted. RESULTS: There was no significant difference in the frequency distribution of ER α gene’s PP, Pp, and pp genotype between MS and NMO case group and control group (P = .598). Frequency distribution of ER α gene’s XX, Xx, and xx was statistically significant between MS and NMO case group and control group (P = .021). Among them, distribution of Xx and Xx gene frequency between patient group and the control group was statistically significant (P = .001, OR = 4.622, 95% CI: 1.803–11.852). There was no significant correlation between ER α genotypes and the onset age in patient group (P > .05). The difference was statistically significant in disease duration of XX and Xx genotype (P = .006). The comparison of Xx and xx genotype frequency distribution in gender exists a difference(P = .047, OR = 7.500, 95% CI: 1.023–54.996). CONCLUSIONS: Xba I gene polymorphisms in the ER α gene have correlation with MS and NMO. Xba I gene could be a risk factor of MS and NMO pathogenesis, especially the women with Xx genotype are more vulnerable. Xba I gene polymorphisms in the ER α gene may impact the disease duration of MS and NMO, or rather, the disease duration of Xx genotype persists longer than Xx genotype. Pvu II gene polymorphisms in the ER α gene has no correlation with MS and NMO.
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spelling pubmed-95757842022-10-17 Correlation between ERα gene polymorphism and multiple sclerosis and neuromyelitis optica Xing, Weifang Hong, Mingfan Wei, Zhisheng Zhang, Wensheng Medicine (Baltimore) 5300 To study the polymorphism distribution of estrogen receptor (ER) α gene and the correlation between different types of polymorphism in multiple sclerosis (MS) and neuromyelitis optica (NMO) patients. METHODS: Forty-six cases of MS and NMO diagnosed from June 2018 to December 2019 were collected. Peripheral venous blood samples were collected. The patient’s gender, age of onset, course of disease, and other clinical data were recorded. Fifty-eight healthy volunteers of the same age and sex were selected. By means of Pvu II and Xba I restriction fragment length polymorphism enzyme recognition sites of ER α gene, polymerase chain reaction-restriction fragment length polymorphism analysis was conducted. RESULTS: There was no significant difference in the frequency distribution of ER α gene’s PP, Pp, and pp genotype between MS and NMO case group and control group (P = .598). Frequency distribution of ER α gene’s XX, Xx, and xx was statistically significant between MS and NMO case group and control group (P = .021). Among them, distribution of Xx and Xx gene frequency between patient group and the control group was statistically significant (P = .001, OR = 4.622, 95% CI: 1.803–11.852). There was no significant correlation between ER α genotypes and the onset age in patient group (P > .05). The difference was statistically significant in disease duration of XX and Xx genotype (P = .006). The comparison of Xx and xx genotype frequency distribution in gender exists a difference(P = .047, OR = 7.500, 95% CI: 1.023–54.996). CONCLUSIONS: Xba I gene polymorphisms in the ER α gene have correlation with MS and NMO. Xba I gene could be a risk factor of MS and NMO pathogenesis, especially the women with Xx genotype are more vulnerable. Xba I gene polymorphisms in the ER α gene may impact the disease duration of MS and NMO, or rather, the disease duration of Xx genotype persists longer than Xx genotype. Pvu II gene polymorphisms in the ER α gene has no correlation with MS and NMO. Lippincott Williams & Wilkins 2022-10-14 /pmc/articles/PMC9575784/ /pubmed/36254093 http://dx.doi.org/10.1097/MD.0000000000031126 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5300
Xing, Weifang
Hong, Mingfan
Wei, Zhisheng
Zhang, Wensheng
Correlation between ERα gene polymorphism and multiple sclerosis and neuromyelitis optica
title Correlation between ERα gene polymorphism and multiple sclerosis and neuromyelitis optica
title_full Correlation between ERα gene polymorphism and multiple sclerosis and neuromyelitis optica
title_fullStr Correlation between ERα gene polymorphism and multiple sclerosis and neuromyelitis optica
title_full_unstemmed Correlation between ERα gene polymorphism and multiple sclerosis and neuromyelitis optica
title_short Correlation between ERα gene polymorphism and multiple sclerosis and neuromyelitis optica
title_sort correlation between erα gene polymorphism and multiple sclerosis and neuromyelitis optica
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575784/
https://www.ncbi.nlm.nih.gov/pubmed/36254093
http://dx.doi.org/10.1097/MD.0000000000031126
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