Cargando…

Random-effects meta-analysis of effect sizes as a unified framework for gene set analysis

Gene set analysis (GSA) remains a common step in genome-scale studies because it can reveal insights that are not apparent from results obtained for individual genes. Many different computational tools are applied for GSA, which may be sensitive to different types of signals; however, most methods i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Makrooni, Mohammad A., O’Shea, Dónal, Geeleher, Paul, Seoighe, Cathal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576052/ https://www.ncbi.nlm.nih.gov/pubmed/36197939 http://dx.doi.org/10.1371/journal.pcbi.1010278

Ejemplares similares

Bias and inconsistency in the estimation of tumour mutation burden
por: Makrooni, Mohammad A., et al.
Publicado: (2022)

Seq-ing improved gene expression estimates from microarrays using machine learning
por: Korir, Paul K., et al.
Publicado: (2015)

Controlling for background genetic effects using polygenic scores improves the power of genome-wide association studies
por: Bennett, Declan, et al.
Publicado: (2021)

The regulatory effect of miRNAs is a heritable genetic trait in humans
por: Geeleher, Paul, et al.
Publicado: (2012)

Investigating the effect of paralogs on microarray gene-set analysis
por: Faure, Andre J, et al.
Publicado: (2011)

Regulatory Landscape Enrichment Analysis (RLEA) using gaiaAssociation
por: Sosa, Eric A., et al.
Publicado: (2023)

Evidence for intron length conservation in a set of mammalian genes associated with embryonic development
por: Seoighe, Cathal, et al.
Publicado: (2011)

Integrative Analysis of mRNA Expression and Half-Life Data Reveals Trans-Acting Genetic Variants Associated with Increased Expression of Stable Transcripts
por: Nguyen, Thong T., et al.
Publicado: (2013)

Cancer expression quantitative trait loci (eQTLs) can be determined from heterogeneous tumor gene expression data by modeling variation in tumor purity
por: Geeleher, Paul, et al.
Publicado: (2018)

vcfView: An Extensible Data Visualization and Quality Assurance Platform for Integrated Somatic Variant Analysis
por: O’Sullivan, Brian, et al.
Publicado: (2020)

LymAnalyzer: a tool for comprehensive analysis of next generation sequencing data of T cell receptors and immunoglobulins
por: Yu, Yaxuan, et al.
Publicado: (2016)

A mutation in a splicing factor that causes retinitis pigmentosa has a transcriptome-wide effect on mRNA splicing
por: Korir, Paul K, et al.
Publicado: (2014)

Unified communication framework
por: Gaisbauer, Dominic, et al.
Publicado: (2016)

The design‐by‐treatment interaction model: a unifying framework for modelling loop inconsistency in network meta‐analysis
por: Jackson, Dan, et al.
Publicado: (2015)

Heritability in the Efficiency of Nonsense-Mediated mRNA Decay in Humans
por: Seoighe, Cathal, et al.
Publicado: (2010)

A flexible R package for nonnegative matrix factorization
por: Gaujoux, Renaud, et al.
Publicado: (2010)

Population Genetics Inference for Longitudinally-Sampled Mutants Under Strong Selection
por: Lacerda, Miguel, et al.
Publicado: (2014)

Inference of Candidate Germline Mutator Loci in Humans from Genome-Wide Haplotype Data
por: Seoighe, Cathal, et al.
Publicado: (2017)

Impact of the Choice of Normalization Method on Molecular Cancer Class Discovery Using Nonnegative Matrix Factorization
por: Yang, Haixuan, et al.
Publicado: (2016)

Substituent directed cellular imaging in the 800–850 nm range with BF(2)-azadipyrromethene fluorophores
por: Caulfield, Cathal, et al.
Publicado: (2023)

A unified framework for joint-tissue transcriptome-wide association and Mendelian Randomization analysis
por: Zhou, Dan, et al.
Publicado: (2020)

Intron Length Coevolution across Mammalian Genomes
por: Keane, Peter A., et al.
Publicado: (2016)

Comprehensive and realistic simulation of tumour genomic sequencing data
por: O’Sullivan, Brian, et al.
Publicado: (2023)

A Unified Framework for Association Analysis with Multiple Related Phenotypes
por: Stephens, Matthew
Publicado: (2013)

PyGNA: a unified framework for geneset network analysis
por: Fanfani, Viola, et al.
Publicado: (2020)

Frequent Toggling between Alternative Amino Acids Is Driven by Selection in HIV-1
por: Delport, Wayne, et al.
Publicado: (2008)

Epitope Discovery with Phylogenetic Hidden Markov Models
por: Lacerda, Miguel, et al.
Publicado: (2010)

No evidence that HLA genotype influences the driver mutations that occur in cancer patients
por: Kherreh, Noor, et al.
Publicado: (2021)

Generalized linear models with random effects: unified analysis via H-likelihood
por: Lee, Youngjo, et al.
Publicado: (2018)

Generalized linear models with random effects: unified analysis via H-likelihood
por: Lee, Youngjo, et al.
Publicado: (2006)

Integrating diverse databases into an unified analysis framework: a Galaxy approach
por: Blankenberg, Daniel, et al.
Publicado: (2011)

Correction: A Unified Framework for Association Analysis with Multiple Related Phenotypes
por: Stephens, Matthew
Publicado: (2019)

A unified framework for analysis of individual-based models in ecology and beyond
por: Cornell, Stephen J., et al.
Publicado: (2019)

A unified and flexible modelling framework for the analysis of malaria serology data
por: Kyomuhangi, Irene, et al.
Publicado: (2021)

Gametophytic Selection in Arabidopsis thaliana Supports the Selective Model of Intron Length Reduction
por: Seoighe, Cathal, et al.
Publicado: (2005)

Evidence of HIV-1 adaptation to host HLA alleles following chimp-to-human transmission
por: Ngandu, Nobubelo K, et al.
Publicado: (2009)

A Unified Framework Integrating Parent-of-Origin Effects for Association Study
por: Xiao, Feifei, et al.
Publicado: (2013)

A unified framework of demographic time
por: Riffe, Tim, et al.
Publicado: (2017)

Active feature elicitation: An unified framework
por: Das, Srijita, et al.
Publicado: (2023)

FRAGS: estimation of coding sequence substitution rates from fragmentary data
por: Swart, Estienne C, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_r53mviglmooc77me24ce8rhk7v