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Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV

Children living with HIV (CLHIV) have decreased bone mineral content (BMC) and density (BMD), increasing risk for fracture and future osteoporosis. While DXA is the gold-standard for bone assessments, it lacks availability in resource-constrained settings (RCS). Quantitative ultrasound (QUS) offers...

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Autores principales: Roberts, Jackson A., Shen, Yanhan, Strehlau, Renate, Patel, Faeezah, Kuhn, Louise, Coovadia, Ashraf, Kaufman, Jonathan J., Shiau, Stephanie, Arpadi, Stephen M., Yin, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576091/
https://www.ncbi.nlm.nih.gov/pubmed/36251674
http://dx.doi.org/10.1371/journal.pone.0276290
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author Roberts, Jackson A.
Shen, Yanhan
Strehlau, Renate
Patel, Faeezah
Kuhn, Louise
Coovadia, Ashraf
Kaufman, Jonathan J.
Shiau, Stephanie
Arpadi, Stephen M.
Yin, Michael T.
author_facet Roberts, Jackson A.
Shen, Yanhan
Strehlau, Renate
Patel, Faeezah
Kuhn, Louise
Coovadia, Ashraf
Kaufman, Jonathan J.
Shiau, Stephanie
Arpadi, Stephen M.
Yin, Michael T.
author_sort Roberts, Jackson A.
collection PubMed
description Children living with HIV (CLHIV) have decreased bone mineral content (BMC) and density (BMD), increasing risk for fracture and future osteoporosis. While DXA is the gold-standard for bone assessments, it lacks availability in resource-constrained settings (RCS). Quantitative ultrasound (QUS) offers an alternative owing to its portability, low cost, ease of handling, and lack of ionizing radiation. While QUS has detected reduced bone quality in CLHIV, the relationship between QUS and DXA in this population remains unexplored. At baseline and 12 months, BMC and BMD of the whole body, lumbar spine, and radius were measured by DXA in a longitudinal cohort of CLHIV in Johannesburg, South Africa. Calcaneal speed of sound (SOS) and broadband ultrasound attenuation (BUA) and radius SOS were obtained by QUS, and calcaneal stiffness index (SI) was calculated. Spearman correlations, with and without HIV stratification, were performed between QUS and DXA measurements at each visit and for absolute difference in measurements between visits. At baseline and 12-months, calcaneal BUA and SI displayed strong positive correlations with DXA, with only modest correlations between radial QUS and DXA at baseline. Longitudinal measures of QUS did not correlate with DXA. At both baseline and 12-months, individuals with DXA whole-body BMD z-score < -1 displayed significantly lower calcaneal BUA and SI. Cross-sectionally, calcaneal QUS correlates strongly with whole body DXA and may represent a viable diagnostic alternative in RCS. Longitudinally, the two methods do not correlate well, possibly reflecting that each method assesses distinct aspects of bone architecture.
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spelling pubmed-95760912022-10-18 Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV Roberts, Jackson A. Shen, Yanhan Strehlau, Renate Patel, Faeezah Kuhn, Louise Coovadia, Ashraf Kaufman, Jonathan J. Shiau, Stephanie Arpadi, Stephen M. Yin, Michael T. PLoS One Research Article Children living with HIV (CLHIV) have decreased bone mineral content (BMC) and density (BMD), increasing risk for fracture and future osteoporosis. While DXA is the gold-standard for bone assessments, it lacks availability in resource-constrained settings (RCS). Quantitative ultrasound (QUS) offers an alternative owing to its portability, low cost, ease of handling, and lack of ionizing radiation. While QUS has detected reduced bone quality in CLHIV, the relationship between QUS and DXA in this population remains unexplored. At baseline and 12 months, BMC and BMD of the whole body, lumbar spine, and radius were measured by DXA in a longitudinal cohort of CLHIV in Johannesburg, South Africa. Calcaneal speed of sound (SOS) and broadband ultrasound attenuation (BUA) and radius SOS were obtained by QUS, and calcaneal stiffness index (SI) was calculated. Spearman correlations, with and without HIV stratification, were performed between QUS and DXA measurements at each visit and for absolute difference in measurements between visits. At baseline and 12-months, calcaneal BUA and SI displayed strong positive correlations with DXA, with only modest correlations between radial QUS and DXA at baseline. Longitudinal measures of QUS did not correlate with DXA. At both baseline and 12-months, individuals with DXA whole-body BMD z-score < -1 displayed significantly lower calcaneal BUA and SI. Cross-sectionally, calcaneal QUS correlates strongly with whole body DXA and may represent a viable diagnostic alternative in RCS. Longitudinally, the two methods do not correlate well, possibly reflecting that each method assesses distinct aspects of bone architecture. Public Library of Science 2022-10-17 /pmc/articles/PMC9576091/ /pubmed/36251674 http://dx.doi.org/10.1371/journal.pone.0276290 Text en © 2022 Roberts et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Roberts, Jackson A.
Shen, Yanhan
Strehlau, Renate
Patel, Faeezah
Kuhn, Louise
Coovadia, Ashraf
Kaufman, Jonathan J.
Shiau, Stephanie
Arpadi, Stephen M.
Yin, Michael T.
Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV
title Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV
title_full Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV
title_fullStr Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV
title_full_unstemmed Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV
title_short Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV
title_sort comparison of quantitative ultrasonography and dual x-ray absorptiometry for bone status assessment in south african children living with hiv
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576091/
https://www.ncbi.nlm.nih.gov/pubmed/36251674
http://dx.doi.org/10.1371/journal.pone.0276290
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