Cargando…

NOS1AP is a novel molecular target and critical factor in TDP-43 pathology

Many lines of evidence have highlighted the role played by heterogeneous nuclear ribonucleoproteins in amyotrophic lateral sclerosis. In this study, we have aimed to identify transcripts co-regulated by TAR DNA-binding protein 43 kDa and highly conserved heterogeneous nuclear ribonucleoproteins whic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cappelli, Sara, Spalloni, Alida, Feiguin, Fabian, Visani, Giulia, Šušnjar, Urša, Brown, Anna-Leigh, De Bardi, Marco, Borsellino, Giovanna, Secrier, Maria, Phatnani, Hemali, Romano, Maurizio, Fratta, Pietro, Longone, Patrizia, Buratti, Emanuele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576154/ https://www.ncbi.nlm.nih.gov/pubmed/36267332 http://dx.doi.org/10.1093/braincomms/fcac242

Ejemplares similares

Cell environment shapes TDP-43 function with implications in neuronal and muscle disease
por: Šušnjar, Urša, et al.
Publicado: (2022)

TDP-43 Epigenetic Facets and Their Neurodegenerative Implications
por: Gimenez, Juliette, et al.
Publicado: (2023)

Drosophila Answers to TDP-43 Proteinopathies
por: Romano, Maurizio, et al.
Publicado: (2012)

Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells
por: Appocher, Chiara, et al.
Publicado: (2017)

Reviewing the Potential Links between Viral Infections and TDP-43 Proteinopathies
por: Rahic, Zerina, et al.
Publicado: (2023)

TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization
por: Godena, Vinay K., et al.
Publicado: (2011)

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
por: Brown, Anna-Leigh, et al.
Publicado: (2022)

TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity
por: Romano, Giulia, et al.
Publicado: (2020)

TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS
por: Romano, Giulia, et al.
Publicado: (2021)

TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins
por: Prpar Mihevc, S., et al.
Publicado: (2016)

Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes
por: Neumann, Manuela, et al.
Publicado: (2020)

Post-transcriptional modifications caused by TDP-43 mutations in mouse and man
por: Fratta, Pietro
Publicado: (2015)

Activation of Phosphotyrosine-Mediated Signaling Pathways in the Cortex and Spinal Cord of SOD1(G93A), a Mouse Model of Familial Amyotrophic Lateral Sclerosis
por: Mallozzi, Cinzia, et al.
Publicado: (2018)

TDP-43 Proteinopathy Specific Biomarker Development
por: Cordts, Isabell, et al.
Publicado: (2023)

Characterizing TDP-43 interaction with its RNA targets
por: Bhardwaj, Amit, et al.
Publicado: (2013)

Unraveling the toxic effects mediated by the neurodegenerative disease–associated S375G mutation of TDP-43 and its S375E phosphomimetic variant
por: Paron, Francesca, et al.
Publicado: (2022)

Glial TDP-43 regulates axon wrapping, GluRIIA clustering and fly motility by autonomous and non-autonomous mechanisms
por: Romano, Giulia, et al.
Publicado: (2015)

Quantitative analysis of cryptic splicing associated with TDP-43 depletion
por: Humphrey, Jack, et al.
Publicado: (2017)

TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles
por: Strah, Nina, et al.
Publicado: (2020)

Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration
por: Marzullo, Marta, et al.
Publicado: (2023)

Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses
por: Romano, Giulia, et al.
Publicado: (2018)

Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation
por: Mompeán, Miguel, et al.
Publicado: (2016)

Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo
por: D’Ambrogio, Andrea, et al.
Publicado: (2009)

A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects
por: Langellotti, Simona, et al.
Publicado: (2016)

Loss of ISWI Function in Drosophila Nuclear Bodies Drives Cytoplasmic Redistribution of Drosophila TDP-43
por: Lo Piccolo, Luca, et al.
Publicado: (2018)

An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds
por: Mompeán, Miguel, et al.
Publicado: (2016)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Zhang, Lumi, et al.
Publicado: (2020)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
por: Deshimaru, Manami, et al.
Publicado: (2021)

SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution
por: Maraschi, AnnaMaria, et al.
Publicado: (2021)

TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways
por: De Conti, Laura, et al.
Publicado: (2015)

Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene
por: Mercado, Pablo Arrisi, et al.
Publicado: (2005)

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
por: Gruijs da Silva, Lara A, et al.
Publicado: (2022)

The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils
por: Scialò, Carlo, et al.
Publicado: (2021)

Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels
por: Prtenjaca, Nikolina, et al.
Publicado: (2022)

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration
por: Gendron, Tania F., et al.
Publicado: (2011)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
por: Ormeño, Fernando, et al.
Publicado: (2020)

Parkin beyond Parkinson’s Disease—A Functional Meaning of Parkin Downregulation in TDP-43 Proteinopathies
por: Gaweda-Walerych, Katarzyna, et al.
Publicado: (2021)

Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72
por: Budini, Mauricio, et al.
Publicado: (2017)

TDP-43 crosses the divide
por: Leslie, Mitch
Publicado: (2015)

Phe-Gly motifs drive fibrillization of TDP-43’s prion-like domain condensates
por: Pantoja-Uceda, David, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c5v8ro2hikk81mt0o3mbp05ake