HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation

Transforming growth factor-β (TGF-β) signaling plays a key role in excessive fibrosis. As a class IIa family histone deacetylase (HDAC), HDAC5 shows a close relationship with TGF-β signaling and fibrosis. However, the effect and regulatory mechanism of HDAC5 in hypertrophic scar (HS) formation remai...

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Detalles Bibliográficos
Autores principales: Gao, Ya, Liu, Yangdan, Zheng, Danning, Ho, Chiakang, Wen, Dongsheng, Sun, Jiaming, Huang, Lu, Liu, Yuxin, Li, Qingfeng, Zhang, Yifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576526/
https://www.ncbi.nlm.nih.gov/pubmed/36263180
http://dx.doi.org/10.7150/ijbs.76140

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