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MiRNA-103 downmodulates CCR5 expression reducing human immunodeficiency virus type-1 entry and impacting latency establishment in CD4(+) T cells
Activated-to-memory transitioning CD4(+) T cells display elevated expression of the HIV-1 co-receptor CCR5 and are more prone to HIV-1 latent infection. Here, we show that p53-regulated miRNA-103 downmodulates CCR5 levels in CD4(+) T lymphocytes. We reveal that miRNA-103 mimics, as well as Nutlin-3,...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576556/ https://www.ncbi.nlm.nih.gov/pubmed/36267915 http://dx.doi.org/10.1016/j.isci.2022.105234 |