MiRNA-103 downmodulates CCR5 expression reducing human immunodeficiency virus type-1 entry and impacting latency establishment in CD4(+) T cells

Activated-to-memory transitioning CD4(+) T cells display elevated expression of the HIV-1 co-receptor CCR5 and are more prone to HIV-1 latent infection. Here, we show that p53-regulated miRNA-103 downmodulates CCR5 levels in CD4(+) T lymphocytes. We reveal that miRNA-103 mimics, as well as Nutlin-3,...

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Detalles Bibliográficos
Autores principales: Bellini, Nicolas, Lodge, Robert, Pham, Tram N.Q., Jain, Jaspreet, Murooka, Thomas T., Herschhorn, Alon, Bernard, Nicole F., Routy, Jean-Pierre, Tremblay, Cécile L., Cohen, Éric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576556/
https://www.ncbi.nlm.nih.gov/pubmed/36267915
http://dx.doi.org/10.1016/j.isci.2022.105234

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