Cargando…

miR-550a-3p is a prognostic biomarker and exerts tumor-suppressive functions by targeting HSP90AA1 in diffuse malignant peritoneal mesothelioma

Diffuse malignant peritoneal mesothelioma (DMPM) is a rare and rapidly lethal tumor, poorly responsive to conventional treatments. In this regards, the identification of molecular alterations underlying DMPM onset and progression might be exploited to develop novel therapeutic strategies. Here, we f...

Descripción completa

Detalles Bibliográficos
Autores principales:	El Bezawy, Rihan, Percio, Stefano, Ciniselli, Chiara Maura, De Cesare, Michelandrea, Colella, Gennaro, Dugo, Matteo, Veneroni, Silvia, Doldi, Valentina, Martini, Silvia, Baratti, Dario, Kusamura, Shigeki, Verderio, Paolo, Deraco, Marcello, Gandellini, Paolo, Zaffaroni, Nadia, Zuco, Valentina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576593/ https://www.ncbi.nlm.nih.gov/pubmed/35352023 http://dx.doi.org/10.1038/s41417-022-00460-7

Ejemplares similares

Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism
por: El Bezawy, Rihan, et al.
Publicado: (2017)

miR-1272 Exerts Tumor-Suppressive Functions in Prostate Cancer via HIP1 Suppression
por: Rotundo, Federica, et al.
Publicado: (2020)

SPOP Deregulation Improves the Radiation Response of Prostate Cancer Models by Impairing DNA Damage Repair
por: El Bezawy, Rihan, et al.
Publicado: (2020)

miR-34a-Mediated Survivin Inhibition Improves the Antitumor Activity of Selinexor in Triple-Negative Breast Cancer
por: Martini, Silvia, et al.
Publicado: (2021)

miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKCε and ZEB1 inhibition
por: El Bezawy, Rihan, et al.
Publicado: (2019)

Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin
por: De Cesare, Michelandrea, et al.
Publicado: (2015)

Prediction of Grade Reclassification of Prostate Cancer Patients on Active Surveillance through the Combination of a Three-miRNA Signature and Selected Clinical Variables
por: Gandellini, Paolo, et al.
Publicado: (2021)

MicroRNAs as Epigenetic Determinants of Treatment Response and Potential Therapeutic Targets in Prostate Cancer
por: Doldi, Valentina, et al.
Publicado: (2021)

LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation
por: Profumo, Valentina, et al.
Publicado: (2019)

Commment on the review entitled “A critical appraisal of hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of advanced and recurrent ovarian cancer” by Chiva LM and Gonzalez-Martin A.
por: Deraco, Marcello, et al.
Publicado: (2015)

Survivin is Highly Expressed and Promotes Cell Survival in Malignant Peritoneal Mesothelioma
por: Zaffaroni, Nadia, et al.
Publicado: (2007)

Selinexor versus doxorubicin in dedifferentiated liposarcoma PDXs: evidence of greater activity and apoptotic response dependent on p53 nuclear accumulation and survivin down‐regulation
por: Zuco, Valentina, et al.
Publicado: (2021)

CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts
por: De Cesare, Michelandrea, et al.
Publicado: (2016)

PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins
por: Zuco, Valentina, et al.
Publicado: (2015)

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma
por: Sciarrillo, Rocco, et al.
Publicado: (2018)

Potential of the Stromal Matricellular Protein Periostin as a Biomarker to Improve Risk Assessment in Prostate Cancer
por: Doldi, Valentina, et al.
Publicado: (2022)

Effectiveness of irinotecan plus trabectedin on a desmoplastic small round cell tumor patient-derived xenograft
por: Zuco, Valentina, et al.
Publicado: (2023)

Molecular Signatures for Combined Targeted Treatments in Diffuse Malignant Peritoneal Mesothelioma
por: Belfiore, Antonino, et al.
Publicado: (2019)

Diagnostic and Therapeutic Pathway in Diffuse Malignant Peritoneal Mesothelioma
por: Kusamura, Shigeki, et al.
Publicado: (2023)

Synergistic Antitumor Effects of Novel HDAC Inhibitors and Paclitaxel In Vitro and In Vivo
por: Zuco, Valentina, et al.
Publicado: (2011)

Telomere as a Therapeutic Target in Dedifferentiated Liposarcoma
por: Alessandrini, Irene, et al.
Publicado: (2022)

Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation
por: Doldi, Valentina, et al.
Publicado: (2015)

Mesothelioma
por: Deraco, Marcello
Publicado: (2021)

Gene expression dataset of prostate cells upon MIR205HG/LEADR modulation
por: Percio, Stefano, et al.
Publicado: (2020)

MIR205HG/LEADR Long Noncoding RNA Binds to Primed Proximal Regulatory Regions in Prostate Basal Cells Through a Triplex- and Alu-Mediated Mechanism
por: Bezzecchi, Eugenia, et al.
Publicado: (2022)

miR-21: an oncomir on strike in prostate cancer
por: Folini, Marco, et al.
Publicado: (2010)

miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an “ALT-like” phenotype in diffuse malignant peritoneal mesothelioma cells
por: Cimino-Reale, Graziella, et al.
Publicado: (2017)

Histone deacetylase inhibitor-temozolomide co-treatment inhibits melanoma growth through suppression of Chemokine (C-C motif) ligand 2-driven signals
por: Gatti, Laura, et al.
Publicado: (2014)

Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types
por: Tazzari, Marcella, et al.
Publicado: (2018)

Developing miRNA signatures: a multivariate prospective
por: Verderio, Paolo, et al.
Publicado: (2016)

Preliminary results of a program for the implementation of laparoscopic colorectal surgery in an Italian comprehensive cancer center during the COVID-19 pandemic
por: Baratti, D., et al.
Publicado: (2022)

Comparative Assessment of Antitumor Effects and Autophagy Induction as a Resistance Mechanism by Cytotoxics and EZH2 Inhibition in INI1-Negative Epithelioid Sarcoma Patient-Derived Xenograft
por: Stacchiotti, Silvia, et al.
Publicado: (2019)

Epithelioid peritoneal mesothelioma: a hybrid phenotype within a mesenchymal-epithelial/epithelial-mesenchymal transition framework
por: Bozzi, Fabio, et al.
Publicado: (2016)

Circulating miRNAs as Novel Non-Invasive Biomarkers to Aid the Early Diagnosis of Suspicious Breast Lesions for Which Biopsy Is Recommended
por: Giussani, Marta, et al.
Publicado: (2021)

Gene signatures of circulating breast cancer cell models are a source of novel molecular determinants of metastasis and improve circulating tumor cell detection in patients
por: Fina, Emanuela, et al.
Publicado: (2022)

1.550 Anécdotas musicales /
por: Barbacci, Rodolfo
Publicado: (1964)

3Rs Principle and Legislative Decrees to Achieve High Standard of Animal Research
por: Verderio, Paolo, et al.
Publicado: (2023)

δ‐Tocotrienol sensitizes and re‐sensitizes ovarian cancer cells to cisplatin via induction of G1 phase cell cycle arrest and ROS/MAPK‐mediated apoptosis
por: Fontana, Fabrizio, et al.
Publicado: (2021)

LEYBOLD pump TMP "550M"
por: Brouet, M, et al.
Publicado: (1978)

Patient-reported outcome measurements in post-mastectomy implant-based breast reconstruction and radiotherapy: Analysis of BREAST-Q data
por: Sala, Laura, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_015icvu99dj4aemgm41ubl5bvu