Protein kinase inhibitor responses in uveal melanoma reflects a diminished dependency on PKC-MAPK signaling

Uveal melanoma (UM) is a rare cancer arising from melanocytes in the uveal tract of the eye. Despite effective primary treatment, there is no approved therapy for metastatic UM and prognosis and survival remain poor. Over 90% of UM are driven by mutations affecting the Gα subunits encoded by the GNA...

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Detalles Bibliográficos
Autores principales: Park, John J., Stewart, Ashleigh, Irvine, Mal, Pedersen, Bernadette, Ming, Zizhen, Carlino, Matteo S., Diefenbach, Russell J., Rizos, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576594/
https://www.ncbi.nlm.nih.gov/pubmed/35352024
http://dx.doi.org/10.1038/s41417-022-00457-2

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