Synthesis, preclinical evaluation and radiation dosimetry of a dual targeting PET tracer [(68)Ga]Ga-FAPI-RGD

To enhance tumor uptake and retention, we designed and developed bi-specific heterodimeric radiotracers targeting both FAP and αvβ3, [(68)Ga]Ga-FAPI-RGD. The present study aimed to evaluate the specificity, pharmacokinetics, and dosimetry of [(68)Ga]Ga-FAPI-RGD by preclinical and preliminary clinica...

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Detalles Bibliográficos
Autores principales: Zang, Jie, Wen, Xuejun, Lin, Rong, Zeng, Xinying, Wang, Chao, Shi, Mengqi, Zeng, Xueyuan, Zhang, Jiaying, Wu, Xiaoming, Zhang, Xianzhong, Miao, Weibing, Xu, Pengfei, Guo, Zhide, Zhang, Jingjing, Chen, Xiaoyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576616/
https://www.ncbi.nlm.nih.gov/pubmed/36276644
http://dx.doi.org/10.7150/thno.79144

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