A new LKB1 activator, piericidin analogue S14, retards renal fibrosis through promoting autophagy and mitochondrial homeostasis in renal tubular epithelial cells

Background: Liver kinase B1 (LKB1) is the key regulator of energy metabolism and cell homeostasis. LKB1 dysfunction plays a key role in renal fibrosis. However, LKB1 activators are scarce in commercial nowadays. This study aims to discover a new drug molecule, piericidin analogue S14 (PA-S14), preve...

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Detalles Bibliográficos
Autores principales: Liu, Canzhen, Wang, Xiaoxu, Wang, Xiaonan, Zhang, Yunfang, Min, Wenjian, Yu, Ping, Miao, Jinhua, Shen, Weiwei, Chen, Shuangqin, Zhou, Shan, Li, Xiaolong, Meng, Ping, Wu, Qinyu, Hou, Fan Fan, Liu, Youhua, Yang, Peng, Wang, Cheng, Lin, Xu, Tang, Lan, Zhou, Xuefeng, Zhou, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576617/
https://www.ncbi.nlm.nih.gov/pubmed/36276641
http://dx.doi.org/10.7150/thno.78376

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