The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes

Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), also known as β-secretase, is an aspartic protease. The sorting of this enzyme into Rab11-positive recycling endosomes regulates the BACE1-mediated cleavage of its substrates, however, the mechanisms underlying this targeting remain poor...

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Detalles Bibliográficos
Autores principales: Keable, Ryan, Hu, Shangfeng, Pfundstein, Grant, Kozlova, Irina, Su, Feifei, Du, Ximing, Yang, Hongyuan, Gunnersen, Jenny, Schachner, Melitta, Leshchyns’ka, Iryna, Sytnyk, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576659/
https://www.ncbi.nlm.nih.gov/pubmed/36251052
http://dx.doi.org/10.1007/s00018-022-04575-w

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