Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

SARS-CoV-2 spread in humans results in continuous emergence of new variants, highlighting the need for vaccines with broad-spectrum antigenic coverage. Using inter-lineage chimera and mutation-patch strategies, we engineered a recombinant monomeric spike variant (STFK1628x) that contains key regions...

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Detalles Bibliográficos
Autores principales: Wu, Yangtao, Wang, Shaojuan, Zhang, Yali, Yuan, Lunzhi, Zheng, Qingbing, Wei, Min, Shi, Yang, Wang, Zikang, Ma, Jian, Wang, Kai, Nie, Meifeng, Xiao, Jin, Huang, Zehong, Chen, Peiwen, Guo, Huilin, Lan, Miaolin, Xu, Jingjing, Hou, Wangheng, Hong, Yunda, Chen, Dabing, Sun, Hui, Xiong, Hualong, Zhou, Ming, Liu, Che, Guo, Wenjie, Guo, Huiyu, Gao, Jiahua, Gan, Congling, Li, Zhixiong, Zhang, Haitao, Wang, Xinrui, Li, Shaowei, Cheng, Tong, Zhao, Qinjian, Chen, Yixin, Wu, Ting, Zhang, Tianying, Zhang, Jun, Cao, Hua, Zhu, Huachen, Yuan, Quan, Guan, Yi, Xia, Ningshao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576691/
https://www.ncbi.nlm.nih.gov/pubmed/36323313
http://dx.doi.org/10.1016/j.chom.2022.10.011

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