The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders

Suicide is a serious public health problem, and it is urgent to identify biomarkers associated with suicide to prevent it. We aimed to clarify the association across suicidal behavior, personality traits, and brain activation by emotional stimulation tasks using near-infrared spectroscopy (NIRS) in...

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Autores principales: Kamimura, Hisashi, Matsuoka, Takahiro, Okai, Hiroshi, Shimizu, Naoki, Harada, Shu, Matsuo, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576702/
https://www.ncbi.nlm.nih.gov/pubmed/36253452
http://dx.doi.org/10.1038/s41598-022-22345-3
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author Kamimura, Hisashi
Matsuoka, Takahiro
Okai, Hiroshi
Shimizu, Naoki
Harada, Shu
Matsuo, Koji
author_facet Kamimura, Hisashi
Matsuoka, Takahiro
Okai, Hiroshi
Shimizu, Naoki
Harada, Shu
Matsuo, Koji
author_sort Kamimura, Hisashi
collection PubMed
description Suicide is a serious public health problem, and it is urgent to identify biomarkers associated with suicide to prevent it. We aimed to clarify the association across suicidal behavior, personality traits, and brain activation by emotional stimulation tasks using near-infrared spectroscopy (NIRS) in patients with mood disorders. 11 mood disorder patients with a history of suicide attempt (MDSA), 18 mood disorder patients with no history of suicide attempt (MDNSA), and 17 healthy individuals were studied. The MDSA patients showed significantly high impulsivity and hopeless compared to healthy subjects, great response to the thread word task in the orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC) compared to MDNSA patients, and the significant correlation between the personality traits and brain activation. The MDNSA did not show the trend. The results suggest that the personality traits and the activation of OFC and DLPFC during the negative emotional cognitive stimuli is associated with suicidal behavior, indicating the findings are involved in the pathophysiology of suicidality in mood disorders.
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spelling pubmed-95767022022-10-19 The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders Kamimura, Hisashi Matsuoka, Takahiro Okai, Hiroshi Shimizu, Naoki Harada, Shu Matsuo, Koji Sci Rep Article Suicide is a serious public health problem, and it is urgent to identify biomarkers associated with suicide to prevent it. We aimed to clarify the association across suicidal behavior, personality traits, and brain activation by emotional stimulation tasks using near-infrared spectroscopy (NIRS) in patients with mood disorders. 11 mood disorder patients with a history of suicide attempt (MDSA), 18 mood disorder patients with no history of suicide attempt (MDNSA), and 17 healthy individuals were studied. The MDSA patients showed significantly high impulsivity and hopeless compared to healthy subjects, great response to the thread word task in the orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC) compared to MDNSA patients, and the significant correlation between the personality traits and brain activation. The MDNSA did not show the trend. The results suggest that the personality traits and the activation of OFC and DLPFC during the negative emotional cognitive stimuli is associated with suicidal behavior, indicating the findings are involved in the pathophysiology of suicidality in mood disorders. Nature Publishing Group UK 2022-10-17 /pmc/articles/PMC9576702/ /pubmed/36253452 http://dx.doi.org/10.1038/s41598-022-22345-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kamimura, Hisashi
Matsuoka, Takahiro
Okai, Hiroshi
Shimizu, Naoki
Harada, Shu
Matsuo, Koji
The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders
title The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders
title_full The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders
title_fullStr The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders
title_full_unstemmed The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders
title_short The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders
title_sort associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576702/
https://www.ncbi.nlm.nih.gov/pubmed/36253452
http://dx.doi.org/10.1038/s41598-022-22345-3
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