Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state

Familial neurohypophyseal diabetes insipidus (FNDI) is a degenerative disease of vasopressin (AVP) neurons. Studies in mouse in vivo models indicate that accumulation of mutant AVP prehormone is associated with FNDI pathology. However, studying human FNDI pathology in vivo is technically challenging...

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Detalles Bibliográficos
Autores principales: Ozaki, Hajime, Suga, Hidetaka, Sakakibara, Mayu, Soen, Mika, Miyake, Natsuki, Miwata, Tsutomu, Taga, Shiori, Nagai, Takashi, Kano, Mayuko, Mitsumoto, Kazuki, Miyata, Takashi, Kobayashi, Tomoko, Sugiyama, Mariko, Onoue, Takeshi, Takagi, Hiroshi, Hagiwara, Daisuke, Iwama, Shintaro, Banno, Ryoichi, Iguchi, Genzo, Takahashi, Yutaka, Muguruma, Keiko, Inoue, Haruhisa, Arima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576732/
https://www.ncbi.nlm.nih.gov/pubmed/36253431
http://dx.doi.org/10.1038/s41598-022-22405-8

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