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A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma
Tumors exhibit enhancer reprogramming compared to normal tissue. The etiology is largely attributed to cell-intrinsic genomic alterations. Here, using freshly resected primary CRC tumors and patient-matched adjacent normal colon, we find divergent epigenetic landscapes between CRC tumors and cell li...
Autores principales: | Zhou, Royce W., Xu, Jia, Martin, Tiphaine C., Zachem, Alexis L., He, John, Ozturk, Sait, Demircioglu, Deniz, Bansal, Ankita, Trotta, Andrew P., Giotti, Bruno, Gryder, Berkley, Shen, Yao, Wu, Xuewei, Carcamo, Saul, Bosch, Kaitlyn, Hopkins, Benjamin, Tsankov, Alexander, Steinhagen, Randolph, Jones, Drew R., Asara, John, Chipuk, Jerry E., Brody, Rachel, Itzkowitz, Steven, Chio, Iok In Christine, Hasson, Dan, Bernstein, Emily, Parsons, Ramon E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576746/ https://www.ncbi.nlm.nih.gov/pubmed/36253360 http://dx.doi.org/10.1038/s41467-022-33377-8 |
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