A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer

Protein neddylation is catalyzed by a neddylation activating enzyme (NAE, E1), an E2 conjugating enzyme, and an E3 ligase. In various types of human cancers, the neddylation pathway is abnormally activated. Our previous study validated that the neddylation E2 UBE2F is a promising therapeutic target...

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Detalles Bibliográficos
Autores principales: Xu, Tiantian, Ma, Qisheng, Li, Yanan, Yu, Qing, Pan, Peichen, Zheng, Yawen, Li, Zhijian, Xiong, Xiufang, Hou, Tingjun, Yu, Bin, Liu, Hongmin, Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576757/
https://www.ncbi.nlm.nih.gov/pubmed/36253371
http://dx.doi.org/10.1038/s41392-022-01182-w

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