A digital platform for the design of patient-centric supply chains

Chimeric Antigen Receptor (CAR) T cell therapies have received increasing attention, showing promising results in the treatment of acute lymphoblastic leukaemia and aggressive B cell lymphoma. Unlike typical cancer treatments, autologous CAR T cell therapies are patient-specific; this makes them a u...

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Autores principales: Triantafyllou, Niki, Bernardi, Andrea, Lakelin, Matthew, Shah, Nilay, Papathanasiou, Maria M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576774/
https://www.ncbi.nlm.nih.gov/pubmed/36253394
http://dx.doi.org/10.1038/s41598-022-21290-5
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author Triantafyllou, Niki
Bernardi, Andrea
Lakelin, Matthew
Shah, Nilay
Papathanasiou, Maria M.
author_facet Triantafyllou, Niki
Bernardi, Andrea
Lakelin, Matthew
Shah, Nilay
Papathanasiou, Maria M.
author_sort Triantafyllou, Niki
collection PubMed
description Chimeric Antigen Receptor (CAR) T cell therapies have received increasing attention, showing promising results in the treatment of acute lymphoblastic leukaemia and aggressive B cell lymphoma. Unlike typical cancer treatments, autologous CAR T cell therapies are patient-specific; this makes them a unique therapeutic to manufacture and distribute. In this work, we focus on the development of a computer modelling tool to assist the design and assessment of supply chain structures that can reliably and cost-efficiently deliver autologous CAR T cell therapies. We focus on four demand scales (200, 500, 1000 and 2000 patients annually) and we assess the tool’s capabilities with respect to the design of responsive supply chain candidate solutions while minimising cost.
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spelling pubmed-95767742022-10-19 A digital platform for the design of patient-centric supply chains Triantafyllou, Niki Bernardi, Andrea Lakelin, Matthew Shah, Nilay Papathanasiou, Maria M. Sci Rep Article Chimeric Antigen Receptor (CAR) T cell therapies have received increasing attention, showing promising results in the treatment of acute lymphoblastic leukaemia and aggressive B cell lymphoma. Unlike typical cancer treatments, autologous CAR T cell therapies are patient-specific; this makes them a unique therapeutic to manufacture and distribute. In this work, we focus on the development of a computer modelling tool to assist the design and assessment of supply chain structures that can reliably and cost-efficiently deliver autologous CAR T cell therapies. We focus on four demand scales (200, 500, 1000 and 2000 patients annually) and we assess the tool’s capabilities with respect to the design of responsive supply chain candidate solutions while minimising cost. Nature Publishing Group UK 2022-10-17 /pmc/articles/PMC9576774/ /pubmed/36253394 http://dx.doi.org/10.1038/s41598-022-21290-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Triantafyllou, Niki
Bernardi, Andrea
Lakelin, Matthew
Shah, Nilay
Papathanasiou, Maria M.
A digital platform for the design of patient-centric supply chains
title A digital platform for the design of patient-centric supply chains
title_full A digital platform for the design of patient-centric supply chains
title_fullStr A digital platform for the design of patient-centric supply chains
title_full_unstemmed A digital platform for the design of patient-centric supply chains
title_short A digital platform for the design of patient-centric supply chains
title_sort digital platform for the design of patient-centric supply chains
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576774/
https://www.ncbi.nlm.nih.gov/pubmed/36253394
http://dx.doi.org/10.1038/s41598-022-21290-5
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