A scalable platform to discover antimicrobials of ribosomal origin

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a promising source of new antimicrobials in the face of rising antibiotic resistance. Here, we report a scalable platform that combines high-throughput bioinformatics with automated biosynthetic gene cluster refactoring f...

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Detalles Bibliográficos
Autores principales: Ayikpoe, Richard S., Shi, Chengyou, Battiste, Alexander J., Eslami, Sara M., Ramesh, Sangeetha, Simon, Max A., Bothwell, Ian R., Lee, Hyunji, Rice, Andrew J., Ren, Hengqian, Tian, Qiqi, Harris, Lonnie A., Sarksian, Raymond, Zhu, Lingyang, Frerk, Autumn M., Precord, Timothy W., van der Donk, Wilfred A., Mitchell, Douglas A., Zhao, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576775/
https://www.ncbi.nlm.nih.gov/pubmed/36253467
http://dx.doi.org/10.1038/s41467-022-33890-w

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