Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke

Stroke is the second leading cause of death with substantial unmet therapeutic needs. To identify potential stroke therapeutic targets, we estimate the causal effects of 308 plasma proteins on stroke outcomes in a two-sample Mendelian randomization framework and assess mediation effects by stroke ri...

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Detalles Bibliográficos
Autores principales: Chen, Lingyan, Peters, James E., Prins, Bram, Persyn, Elodie, Traylor, Matthew, Surendran, Praveen, Karthikeyan, Savita, Yonova-Doing, Ekaterina, Di Angelantonio, Emanuele, Roberts, David J., Watkins, Nicholas A., Ouwehand, Willem H., Danesh, John, Lewis, Cathryn M., Bronson, Paola G., Markus, Hugh S., Burgess, Stephen, Butterworth, Adam S., Howson, Joanna M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576777/
https://www.ncbi.nlm.nih.gov/pubmed/36253349
http://dx.doi.org/10.1038/s41467-022-33675-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576777/
https://www.ncbi.nlm.nih.gov/pubmed/36253349
http://dx.doi.org/10.1038/s41467-022-33675-1

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