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A systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults

Sleep-disordered breathing (SDB) is characterized by repeated breathing pauses during sleep. The prevalence of SDB varies widely between studies. Some longitudinal studies have found an association of SDB with incident or recurrent cardiovascular events. We sought to systematically describe the curr...

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Autores principales: Khokhrina, Anna, Andreeva, Elena, Degryse, Jean-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576790/
https://www.ncbi.nlm.nih.gov/pubmed/36253378
http://dx.doi.org/10.1038/s41533-022-00307-6
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author Khokhrina, Anna
Andreeva, Elena
Degryse, Jean-Marie
author_facet Khokhrina, Anna
Andreeva, Elena
Degryse, Jean-Marie
author_sort Khokhrina, Anna
collection PubMed
description Sleep-disordered breathing (SDB) is characterized by repeated breathing pauses during sleep. The prevalence of SDB varies widely between studies. Some longitudinal studies have found an association of SDB with incident or recurrent cardiovascular events. We sought to systematically describe the current data on the correlation between SDB and cardiovascular pathology. Studies were included if they were original observational population-based studies in adults with clearly diagnosed SDB. The primary outcomes include all types of cardiovascular pathology. We carried out pooled analyses using a random effects model. Our systematic review was performed according to the PRISMA and MOOSE guidelines for systematic reviews and was registered with PROSPERO. In total, 2652 articles were detected in the databases, of which 76 articles were chosen for full-text review. Fourteen studies were focused on samples of an unselected population, and 8 studies were focused on a group of persons at risk for SDB. In 5 studies, the incidence of cardiovascular pathology in the population with SDB was examined. In total, 49 studies described SDB in patients with cardiovascular pathology. We found an association between SDB and prevalent /incident cardiovascular disease (pooled OR 1.76; 95% CI 1.38–2.26), and pooled HR (95% CI 1.78; 95% CI 1.34–2.45). Notably, in patients with existing SDB, the risk of new adverse cardiovascular events was high. However, the relationship between cardiovascular disease and SDB is likely to be bidirectional. Thus, more large-scale studies are needed to better understand this association and to decide whether screening for possible SDB in cardiovascular patients is reasonable and clinically significant.
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spelling pubmed-95767902022-10-19 A systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults Khokhrina, Anna Andreeva, Elena Degryse, Jean-Marie NPJ Prim Care Respir Med Review Article Sleep-disordered breathing (SDB) is characterized by repeated breathing pauses during sleep. The prevalence of SDB varies widely between studies. Some longitudinal studies have found an association of SDB with incident or recurrent cardiovascular events. We sought to systematically describe the current data on the correlation between SDB and cardiovascular pathology. Studies were included if they were original observational population-based studies in adults with clearly diagnosed SDB. The primary outcomes include all types of cardiovascular pathology. We carried out pooled analyses using a random effects model. Our systematic review was performed according to the PRISMA and MOOSE guidelines for systematic reviews and was registered with PROSPERO. In total, 2652 articles were detected in the databases, of which 76 articles were chosen for full-text review. Fourteen studies were focused on samples of an unselected population, and 8 studies were focused on a group of persons at risk for SDB. In 5 studies, the incidence of cardiovascular pathology in the population with SDB was examined. In total, 49 studies described SDB in patients with cardiovascular pathology. We found an association between SDB and prevalent /incident cardiovascular disease (pooled OR 1.76; 95% CI 1.38–2.26), and pooled HR (95% CI 1.78; 95% CI 1.34–2.45). Notably, in patients with existing SDB, the risk of new adverse cardiovascular events was high. However, the relationship between cardiovascular disease and SDB is likely to be bidirectional. Thus, more large-scale studies are needed to better understand this association and to decide whether screening for possible SDB in cardiovascular patients is reasonable and clinically significant. Nature Publishing Group UK 2022-10-17 /pmc/articles/PMC9576790/ /pubmed/36253378 http://dx.doi.org/10.1038/s41533-022-00307-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Khokhrina, Anna
Andreeva, Elena
Degryse, Jean-Marie
A systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults
title A systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults
title_full A systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults
title_fullStr A systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults
title_full_unstemmed A systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults
title_short A systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults
title_sort systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576790/
https://www.ncbi.nlm.nih.gov/pubmed/36253378
http://dx.doi.org/10.1038/s41533-022-00307-6
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