Discovery of small molecule inhibitors that effectively disrupt IQGAP1-Cdc42 interaction in breast cancer cells

The small GTPase Cdc42 is an integral component of the cytoskeleton, and its dysregulation leads to pathophysiological conditions, such as cancer. Binding of Cdc42 to the scaffold protein IQGAP1 stabilizes Cdc42 in its active form. The interaction between Cdc42 and IQGAP1 enhances migration and inva...

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Detalles Bibliográficos
Autores principales: Sayedyahossein, Samar, Smith, Jessica, Barnaeva, Elena, Li, Zhigang, Choe, Jun, Ronzetti, Michael, Dextras, Christopher, Hu, Xin, Marugan, Juan, Southall, Noel, Baljinnyam, Bolormaa, Thines, Louise, Tran, Andy D., Ferrer, Marc, Sacks, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576799/
https://www.ncbi.nlm.nih.gov/pubmed/36253497
http://dx.doi.org/10.1038/s41598-022-21342-w

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