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An update of polycystic ovary syndrome: causes and therapeutics options

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by menstrual irregularities, chronic anovulation, hirsutism, androgenic alopecia, and acne. At diagnosis, patients can with different manifestations according to the disease phenotype, patient’s age, and lifestyle. However, m...

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Detalles Bibliográficos
Autores principales: Rababa’h, Abeer M., Matani, Bayan R., Yehya, Alaa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576888/
https://www.ncbi.nlm.nih.gov/pubmed/36267367
http://dx.doi.org/10.1016/j.heliyon.2022.e11010
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author Rababa’h, Abeer M.
Matani, Bayan R.
Yehya, Alaa
author_facet Rababa’h, Abeer M.
Matani, Bayan R.
Yehya, Alaa
author_sort Rababa’h, Abeer M.
collection PubMed
description Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by menstrual irregularities, chronic anovulation, hirsutism, androgenic alopecia, and acne. At diagnosis, patients can with different manifestations according to the disease phenotype, patient’s age, and lifestyle. However, most patients pursue medical care because of the clinical symptoms of PCOS, such as hyperandrogenism, menstrual irregularities and infertility. Recent studies have shown that PCOS is associated with 80% of anovulatory infertility; however, the precise mechanism of PCOS-induced anovulation is still undetermined. The treatment strategies of PCOS are symptomatic depending mainly on the desired goals and clinical benefits. Life style intervention is still the first line treatment option for overweight females seeking pregnancy. In addition, there are many pharmacological agents that could be added to induce ovulation such as metformin, and clomiphene citrate. Nowadays, many patients preferred to use some herbal medicine that was proved to have potential therapeutic benefits in many studies in the management of PCOS. The purpose of this review was to discuss PCOS-induced infertility and the available therapeutic options as well as the impact of COVID-19 infection on the success of fertility attempts. To address this purpose, Pubmed, Scopus, EMBASE and Google databases were searched for studies discussing PCOS-induced infertility. The literature search revealed the proper therapeutic plans to treat PCOS-induced infertility, and that treatment should be modified according to patient’s complaints, reproductive desires, and disease phenotypes. In conclusion, the use of specific therapeutic agents and patients’ adherence to lifestyle interventions could help patients recover their reproductive and metabolic health.
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spelling pubmed-95768882022-10-19 An update of polycystic ovary syndrome: causes and therapeutics options Rababa’h, Abeer M. Matani, Bayan R. Yehya, Alaa Heliyon Research Article Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by menstrual irregularities, chronic anovulation, hirsutism, androgenic alopecia, and acne. At diagnosis, patients can with different manifestations according to the disease phenotype, patient’s age, and lifestyle. However, most patients pursue medical care because of the clinical symptoms of PCOS, such as hyperandrogenism, menstrual irregularities and infertility. Recent studies have shown that PCOS is associated with 80% of anovulatory infertility; however, the precise mechanism of PCOS-induced anovulation is still undetermined. The treatment strategies of PCOS are symptomatic depending mainly on the desired goals and clinical benefits. Life style intervention is still the first line treatment option for overweight females seeking pregnancy. In addition, there are many pharmacological agents that could be added to induce ovulation such as metformin, and clomiphene citrate. Nowadays, many patients preferred to use some herbal medicine that was proved to have potential therapeutic benefits in many studies in the management of PCOS. The purpose of this review was to discuss PCOS-induced infertility and the available therapeutic options as well as the impact of COVID-19 infection on the success of fertility attempts. To address this purpose, Pubmed, Scopus, EMBASE and Google databases were searched for studies discussing PCOS-induced infertility. The literature search revealed the proper therapeutic plans to treat PCOS-induced infertility, and that treatment should be modified according to patient’s complaints, reproductive desires, and disease phenotypes. In conclusion, the use of specific therapeutic agents and patients’ adherence to lifestyle interventions could help patients recover their reproductive and metabolic health. Elsevier 2022-10-10 /pmc/articles/PMC9576888/ /pubmed/36267367 http://dx.doi.org/10.1016/j.heliyon.2022.e11010 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Rababa’h, Abeer M.
Matani, Bayan R.
Yehya, Alaa
An update of polycystic ovary syndrome: causes and therapeutics options
title An update of polycystic ovary syndrome: causes and therapeutics options
title_full An update of polycystic ovary syndrome: causes and therapeutics options
title_fullStr An update of polycystic ovary syndrome: causes and therapeutics options
title_full_unstemmed An update of polycystic ovary syndrome: causes and therapeutics options
title_short An update of polycystic ovary syndrome: causes and therapeutics options
title_sort update of polycystic ovary syndrome: causes and therapeutics options
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576888/
https://www.ncbi.nlm.nih.gov/pubmed/36267367
http://dx.doi.org/10.1016/j.heliyon.2022.e11010
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