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The therapeutic effect and mechanism of melatonin on osteoarthritis: From the perspective of non-coding RNAs
Osteoarthritis (OA) is a slowly progressing and irreversible joint disease. The existing non-surgical treatment can only delay its progress, making the early treatment of OA a research hotspot in recent years. Melatonin, a neurohormone mainly secreted by the pineal gland, has a variety of regulatory...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576930/ https://www.ncbi.nlm.nih.gov/pubmed/36267400 http://dx.doi.org/10.3389/fgene.2022.968919 |
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author | Li, Shuai Si, Haibo Xu, Jiawen Liu, Yuan Shen, Bin |
author_facet | Li, Shuai Si, Haibo Xu, Jiawen Liu, Yuan Shen, Bin |
author_sort | Li, Shuai |
collection | PubMed |
description | Osteoarthritis (OA) is a slowly progressing and irreversible joint disease. The existing non-surgical treatment can only delay its progress, making the early treatment of OA a research hotspot in recent years. Melatonin, a neurohormone mainly secreted by the pineal gland, has a variety of regulatory functions in different organs, and numerous studies have confirmed its therapeutic effect on OA. Non-coding RNAs (ncRNAs) constitute the majority of the human transcribed genome. Various ncRNAs show significant differentially expressed between healthy people and OA patients. ncRNAs play diverse roles in many cellular processes and have been implicated in many pathological conditions, especially OA. Interestingly, the latest research found a close interaction between ncRNAs and melatonin in regulating the pathogenesis of OA. This review discusses the current understanding of the melatonin-mediated modulation of ncRNAs in the early stage of OA. We also delineate the potential link between rhythm genes and ncRNAs in chondrocytes. This review will serve as a solid foundation to formulate ideas for future mechanistic studies on the therapeutic potential of melatonin and ncRNAs in OA and better explore the emerging functions of the ncRNAs. |
format | Online Article Text |
id | pubmed-9576930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95769302022-10-19 The therapeutic effect and mechanism of melatonin on osteoarthritis: From the perspective of non-coding RNAs Li, Shuai Si, Haibo Xu, Jiawen Liu, Yuan Shen, Bin Front Genet Genetics Osteoarthritis (OA) is a slowly progressing and irreversible joint disease. The existing non-surgical treatment can only delay its progress, making the early treatment of OA a research hotspot in recent years. Melatonin, a neurohormone mainly secreted by the pineal gland, has a variety of regulatory functions in different organs, and numerous studies have confirmed its therapeutic effect on OA. Non-coding RNAs (ncRNAs) constitute the majority of the human transcribed genome. Various ncRNAs show significant differentially expressed between healthy people and OA patients. ncRNAs play diverse roles in many cellular processes and have been implicated in many pathological conditions, especially OA. Interestingly, the latest research found a close interaction between ncRNAs and melatonin in regulating the pathogenesis of OA. This review discusses the current understanding of the melatonin-mediated modulation of ncRNAs in the early stage of OA. We also delineate the potential link between rhythm genes and ncRNAs in chondrocytes. This review will serve as a solid foundation to formulate ideas for future mechanistic studies on the therapeutic potential of melatonin and ncRNAs in OA and better explore the emerging functions of the ncRNAs. Frontiers Media S.A. 2022-10-04 /pmc/articles/PMC9576930/ /pubmed/36267400 http://dx.doi.org/10.3389/fgene.2022.968919 Text en Copyright © 2022 Li, Si, Xu, Liu and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Li, Shuai Si, Haibo Xu, Jiawen Liu, Yuan Shen, Bin The therapeutic effect and mechanism of melatonin on osteoarthritis: From the perspective of non-coding RNAs |
title | The therapeutic effect and mechanism of melatonin on osteoarthritis: From the perspective of non-coding RNAs |
title_full | The therapeutic effect and mechanism of melatonin on osteoarthritis: From the perspective of non-coding RNAs |
title_fullStr | The therapeutic effect and mechanism of melatonin on osteoarthritis: From the perspective of non-coding RNAs |
title_full_unstemmed | The therapeutic effect and mechanism of melatonin on osteoarthritis: From the perspective of non-coding RNAs |
title_short | The therapeutic effect and mechanism of melatonin on osteoarthritis: From the perspective of non-coding RNAs |
title_sort | therapeutic effect and mechanism of melatonin on osteoarthritis: from the perspective of non-coding rnas |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576930/ https://www.ncbi.nlm.nih.gov/pubmed/36267400 http://dx.doi.org/10.3389/fgene.2022.968919 |
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