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Rapidly progressive Guillain–Barré syndrome following amitriptyline overdose and severe Klebsiella pneumoniae infection: A case report and literature review

Guillain–Barré syndrome (GBS) is a potentially life-threatening post-infectious autoimmune disease characterized by rapidly progressive symmetrical weakness of the extremities. Herein, we report a case of GBS associated with drug poisoning complicated by Klebsiella pneumoniae infection. A 38-year-ol...

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Autores principales: Zhang, Boyu, Duan, Liwei, Ma, Linhao, Cai, Qingqing, Wu, Hao, Chang, Liang, Li, Wenfang, Lin, Zhaofen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576939/
https://www.ncbi.nlm.nih.gov/pubmed/36267621
http://dx.doi.org/10.3389/fmed.2022.991182
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author Zhang, Boyu
Duan, Liwei
Ma, Linhao
Cai, Qingqing
Wu, Hao
Chang, Liang
Li, Wenfang
Lin, Zhaofen
author_facet Zhang, Boyu
Duan, Liwei
Ma, Linhao
Cai, Qingqing
Wu, Hao
Chang, Liang
Li, Wenfang
Lin, Zhaofen
author_sort Zhang, Boyu
collection PubMed
description Guillain–Barré syndrome (GBS) is a potentially life-threatening post-infectious autoimmune disease characterized by rapidly progressive symmetrical weakness of the extremities. Herein, we report a case of GBS associated with drug poisoning complicated by Klebsiella pneumoniae infection. A 38-year-old woman was admitted to the intensive care unit after taking an overdose of amitriptyline and was later diagnosed with coma, Klebsiella pneumoniae infection, and septic shock. Thirteen days after admission, she was diagnosed with GBS based on acute muscle pain, flaccid paralysis, hyporeflexia, reduced amplitude of compound muscle action potential, and albuminocytologic dissociation in the cerebrospinal fluid. GBS rarely occurs after a drug overdose and septic shock, and this is the first report of a rapidly progressive GBS following amitriptyline overdose and severe Klebsiella pneumoniae infection.
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spelling pubmed-95769392022-10-19 Rapidly progressive Guillain–Barré syndrome following amitriptyline overdose and severe Klebsiella pneumoniae infection: A case report and literature review Zhang, Boyu Duan, Liwei Ma, Linhao Cai, Qingqing Wu, Hao Chang, Liang Li, Wenfang Lin, Zhaofen Front Med (Lausanne) Medicine Guillain–Barré syndrome (GBS) is a potentially life-threatening post-infectious autoimmune disease characterized by rapidly progressive symmetrical weakness of the extremities. Herein, we report a case of GBS associated with drug poisoning complicated by Klebsiella pneumoniae infection. A 38-year-old woman was admitted to the intensive care unit after taking an overdose of amitriptyline and was later diagnosed with coma, Klebsiella pneumoniae infection, and septic shock. Thirteen days after admission, she was diagnosed with GBS based on acute muscle pain, flaccid paralysis, hyporeflexia, reduced amplitude of compound muscle action potential, and albuminocytologic dissociation in the cerebrospinal fluid. GBS rarely occurs after a drug overdose and septic shock, and this is the first report of a rapidly progressive GBS following amitriptyline overdose and severe Klebsiella pneumoniae infection. Frontiers Media S.A. 2022-10-04 /pmc/articles/PMC9576939/ /pubmed/36267621 http://dx.doi.org/10.3389/fmed.2022.991182 Text en Copyright © 2022 Zhang, Duan, Ma, Cai, Wu, Chang, Li and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zhang, Boyu
Duan, Liwei
Ma, Linhao
Cai, Qingqing
Wu, Hao
Chang, Liang
Li, Wenfang
Lin, Zhaofen
Rapidly progressive Guillain–Barré syndrome following amitriptyline overdose and severe Klebsiella pneumoniae infection: A case report and literature review
title Rapidly progressive Guillain–Barré syndrome following amitriptyline overdose and severe Klebsiella pneumoniae infection: A case report and literature review
title_full Rapidly progressive Guillain–Barré syndrome following amitriptyline overdose and severe Klebsiella pneumoniae infection: A case report and literature review
title_fullStr Rapidly progressive Guillain–Barré syndrome following amitriptyline overdose and severe Klebsiella pneumoniae infection: A case report and literature review
title_full_unstemmed Rapidly progressive Guillain–Barré syndrome following amitriptyline overdose and severe Klebsiella pneumoniae infection: A case report and literature review
title_short Rapidly progressive Guillain–Barré syndrome following amitriptyline overdose and severe Klebsiella pneumoniae infection: A case report and literature review
title_sort rapidly progressive guillain–barré syndrome following amitriptyline overdose and severe klebsiella pneumoniae infection: a case report and literature review
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576939/
https://www.ncbi.nlm.nih.gov/pubmed/36267621
http://dx.doi.org/10.3389/fmed.2022.991182
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