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Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders

Extensive research has implicated inflammation and oxidative stress in the development of multiple diseases, such as diabetes, hepatitis, and arthritis. Kinsenoside (KD), a bioactive glycoside component extracted from the medicinal plant Anoectochilus roxburghii, has been shown to exhibit potent ant...

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Autores principales: Lu, Li, Xiong, Yuan, Lin, Ze, Chu, Xiangyu, Panayi, Adriana C., Hu, Yiqiang, Zhou, Juan, Mi, Bobin, Liu, Guohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576948/
https://www.ncbi.nlm.nih.gov/pubmed/36267286
http://dx.doi.org/10.3389/fphar.2022.1009550
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author Lu, Li
Xiong, Yuan
Lin, Ze
Chu, Xiangyu
Panayi, Adriana C.
Hu, Yiqiang
Zhou, Juan
Mi, Bobin
Liu, Guohui
author_facet Lu, Li
Xiong, Yuan
Lin, Ze
Chu, Xiangyu
Panayi, Adriana C.
Hu, Yiqiang
Zhou, Juan
Mi, Bobin
Liu, Guohui
author_sort Lu, Li
collection PubMed
description Extensive research has implicated inflammation and oxidative stress in the development of multiple diseases, such as diabetes, hepatitis, and arthritis. Kinsenoside (KD), a bioactive glycoside component extracted from the medicinal plant Anoectochilus roxburghii, has been shown to exhibit potent anti-inflammatory and anti-oxidative abilities. In this review, we summarize multiple effects of KD, including hepatoprotection, pro-osteogenesis, anti-hyperglycemia, vascular protection, immune regulation, vision protection, and infection inhibition, which are partly responsible for suppressing inflammation signaling and oxidative stress. The protective action of KD against dysfunctional lipid metabolism is also associated with limiting inflammatory signals, due to the crosstalk between inflammation and lipid metabolism. Ferroptosis, a process involved in both inflammation and oxidative damage, is potentially regulated by KD. In addition, we discuss the physicochemical properties and pharmacokinetic profiles of KD. Advances in cultivation and artificial synthesis techniques are promising evidence that the shortage in raw materials required for KD production can be overcome. In addition, novel drug delivery systems can improve the in vivo rapid clearance and poor bioavailability of KD. In this integrated review, we aim to offer novel insights into the molecular mechanisms underlying the therapeutic role of KD and lay solid foundations for the utilization of KD in clinical practice.
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spelling pubmed-95769482022-10-19 Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders Lu, Li Xiong, Yuan Lin, Ze Chu, Xiangyu Panayi, Adriana C. Hu, Yiqiang Zhou, Juan Mi, Bobin Liu, Guohui Front Pharmacol Pharmacology Extensive research has implicated inflammation and oxidative stress in the development of multiple diseases, such as diabetes, hepatitis, and arthritis. Kinsenoside (KD), a bioactive glycoside component extracted from the medicinal plant Anoectochilus roxburghii, has been shown to exhibit potent anti-inflammatory and anti-oxidative abilities. In this review, we summarize multiple effects of KD, including hepatoprotection, pro-osteogenesis, anti-hyperglycemia, vascular protection, immune regulation, vision protection, and infection inhibition, which are partly responsible for suppressing inflammation signaling and oxidative stress. The protective action of KD against dysfunctional lipid metabolism is also associated with limiting inflammatory signals, due to the crosstalk between inflammation and lipid metabolism. Ferroptosis, a process involved in both inflammation and oxidative damage, is potentially regulated by KD. In addition, we discuss the physicochemical properties and pharmacokinetic profiles of KD. Advances in cultivation and artificial synthesis techniques are promising evidence that the shortage in raw materials required for KD production can be overcome. In addition, novel drug delivery systems can improve the in vivo rapid clearance and poor bioavailability of KD. In this integrated review, we aim to offer novel insights into the molecular mechanisms underlying the therapeutic role of KD and lay solid foundations for the utilization of KD in clinical practice. Frontiers Media S.A. 2022-10-04 /pmc/articles/PMC9576948/ /pubmed/36267286 http://dx.doi.org/10.3389/fphar.2022.1009550 Text en Copyright © 2022 Lu, Xiong, Lin, Chu, Panayi, Hu, Zhou, Mi and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lu, Li
Xiong, Yuan
Lin, Ze
Chu, Xiangyu
Panayi, Adriana C.
Hu, Yiqiang
Zhou, Juan
Mi, Bobin
Liu, Guohui
Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders
title Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders
title_full Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders
title_fullStr Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders
title_full_unstemmed Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders
title_short Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders
title_sort advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576948/
https://www.ncbi.nlm.nih.gov/pubmed/36267286
http://dx.doi.org/10.3389/fphar.2022.1009550
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