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Antioxidant and anti-inflammatory activity of constituents isolated from Dendrobium nobile (Lindl.)

Dendrobium nobile (Lindl.) have long been used as herbal tea and a traditional herbal medicine to treat Alzheimer’s disease (AD). In the current study, nineteen compounds (1–19), including two new vitamin E homologues (1–2), one new sesquiterpene (6), and two new dendrobines (7, 8), were isolated an...

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Detalles Bibliográficos
Autores principales: Lei, Hui, Zou, Shunmei, Lin, Jiafu, Zhai, Longfei, Zhang, Yifeng, Fu, Xiujuan, Chen, Siwei, Niu, Hong, Liu, Feifei, Wu, Chunlian, Zhang, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577000/
https://www.ncbi.nlm.nih.gov/pubmed/36267656
http://dx.doi.org/10.3389/fchem.2022.988459
Descripción
Sumario:Dendrobium nobile (Lindl.) have long been used as herbal tea and a traditional herbal medicine to treat Alzheimer’s disease (AD). In the current study, nineteen compounds (1–19), including two new vitamin E homologues (1–2), one new sesquiterpene (6), and two new dendrobines (7, 8), were isolated and identified from stems of Dendrobium nobile. Their structures were elucidated on the basis of NMR, (13)C NMR calculation, and DP4(+) probability analyses. The absolute configurations of new compounds were determined by electronic circular dichroism (ECD) data analysis. Antioxidant, anti-inflammatory, and cytotoxic activities of isolated compounds were evaluated. Among them, compound 2 demonstrated significant antioxidant activity compared with ascorbic acid (VC), while compounds 2 and 4 also exhibited an equal effect to positive control cisplatin. This study on the biological activity of the new vitamin E homologues from Dendrobium nobile may indicate its potential application in the pharmaceutical and food industries.