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Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy

A case of renal dysplasia (RD) in the Welsh Corgi dog has been reported. Clinically, the affected 3-month-old, female, Welsh Corgi dog showed unclear symptoms of chronic kidney disease. Grossly, both left and right kidneys revealed cystic hypoplasia. Histologically, the primary lesions included imma...

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Autores principales: Le, Trung Quang, Pluemhathaikij, Latticha, Chankow, Katriya, Radtanakatikanon, Araya, Rungsipipat, Anudep, Rattanapinyopituk, Kasem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577014/
https://www.ncbi.nlm.nih.gov/pubmed/36268045
http://dx.doi.org/10.3389/fvets.2022.995765
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author Le, Trung Quang
Pluemhathaikij, Latticha
Chankow, Katriya
Radtanakatikanon, Araya
Rungsipipat, Anudep
Rattanapinyopituk, Kasem
author_facet Le, Trung Quang
Pluemhathaikij, Latticha
Chankow, Katriya
Radtanakatikanon, Araya
Rungsipipat, Anudep
Rattanapinyopituk, Kasem
author_sort Le, Trung Quang
collection PubMed
description A case of renal dysplasia (RD) in the Welsh Corgi dog has been reported. Clinically, the affected 3-month-old, female, Welsh Corgi dog showed unclear symptoms of chronic kidney disease. Grossly, both left and right kidneys revealed cystic hypoplasia. Histologically, the primary lesions included immature or fetal glomeruli/tubules, proliferative arterioles, persistent metanephric ducts, persistent mesenchyme, and atypical tubular epithelium were presented. A group of degenerative and inflammatory lesions consisting of interstitial nephritis, interstitial fibrosis, and mineralization of tubules were found. Immunohistochemically, the epithelial cells of immature (fetal) tubules had BCL-2 labeling whereas CD31 (PECAM-1) was labeled in the endothelial cells of the proliferative arterioles. The immunohistochemical findings were confirmed and consolidated with the routine histopathological findings. This study was the first demonstration of the clinical, histopathological, and immunohistochemical features of RD disease in a Welsh Corgi puppy.
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spelling pubmed-95770142022-10-19 Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy Le, Trung Quang Pluemhathaikij, Latticha Chankow, Katriya Radtanakatikanon, Araya Rungsipipat, Anudep Rattanapinyopituk, Kasem Front Vet Sci Veterinary Science A case of renal dysplasia (RD) in the Welsh Corgi dog has been reported. Clinically, the affected 3-month-old, female, Welsh Corgi dog showed unclear symptoms of chronic kidney disease. Grossly, both left and right kidneys revealed cystic hypoplasia. Histologically, the primary lesions included immature or fetal glomeruli/tubules, proliferative arterioles, persistent metanephric ducts, persistent mesenchyme, and atypical tubular epithelium were presented. A group of degenerative and inflammatory lesions consisting of interstitial nephritis, interstitial fibrosis, and mineralization of tubules were found. Immunohistochemically, the epithelial cells of immature (fetal) tubules had BCL-2 labeling whereas CD31 (PECAM-1) was labeled in the endothelial cells of the proliferative arterioles. The immunohistochemical findings were confirmed and consolidated with the routine histopathological findings. This study was the first demonstration of the clinical, histopathological, and immunohistochemical features of RD disease in a Welsh Corgi puppy. Frontiers Media S.A. 2022-10-04 /pmc/articles/PMC9577014/ /pubmed/36268045 http://dx.doi.org/10.3389/fvets.2022.995765 Text en Copyright © 2022 Le, Pluemhathaikij, Chankow, Radtanakatikanon, Rungsipipat and Rattanapinyopituk. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Le, Trung Quang
Pluemhathaikij, Latticha
Chankow, Katriya
Radtanakatikanon, Araya
Rungsipipat, Anudep
Rattanapinyopituk, Kasem
Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy
title Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy
title_full Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy
title_fullStr Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy
title_full_unstemmed Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy
title_short Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy
title_sort case report: bcl-2 and cd31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a welsh corgi puppy
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577014/
https://www.ncbi.nlm.nih.gov/pubmed/36268045
http://dx.doi.org/10.3389/fvets.2022.995765
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