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Relationship between bullous pemphigoid and metabolic syndrome: a 12-year case–control study conducted in China

BACKGROUND: Hypertension, diabetes, dyslipidemia, and obesity are prevalent in patients with bullous pemphigoid (BP) and are all components of metabolic syndrome (MS). However, the prevalence of MS in patients with BP is unknown. We aimed to evaluate the relationship between MS and BP and to define...

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Autores principales: Zhang, Bingjie, Chen, Xinyi, Liu, Yangchun, Chen, Fangyuan, Yang, Nan, Li, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577067/
https://www.ncbi.nlm.nih.gov/pubmed/36267486
http://dx.doi.org/10.1177/20406223221130707
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author Zhang, Bingjie
Chen, Xinyi
Liu, Yangchun
Chen, Fangyuan
Yang, Nan
Li, Li
author_facet Zhang, Bingjie
Chen, Xinyi
Liu, Yangchun
Chen, Fangyuan
Yang, Nan
Li, Li
author_sort Zhang, Bingjie
collection PubMed
description BACKGROUND: Hypertension, diabetes, dyslipidemia, and obesity are prevalent in patients with bullous pemphigoid (BP) and are all components of metabolic syndrome (MS). However, the prevalence of MS in patients with BP is unknown. We aimed to evaluate the relationship between MS and BP and to define the clinical and laboratory characteristics of patients with both conditions. METHODS: This retrospective case–control study was conducted for 12 years at Peking Union Medical College (162 with BP and 162 age and sex-matched controls). The components of MS were analyzed and logistic regression was used to identify independent risk factors for BP. In addition, the clinical and laboratory characteristics of patients with BP ± MS were compared. RESULTS: The prevalence of MS in patients with BP was 35.2% and that in controls was 14.8% (p < 0.001). After adjustment for sex and age, multivariate analysis demonstrated a positive correlation between BP and MS [odds ratio (OR) 2.490, 95% confidence interval (CI) 1.040–5.963], diabetes (OR 1.870, 95% CI 1.029–3.396), and overweight or obesity (OR 1.807, 95% CI 1.026–3.182). In the BP group, participants with MS were older (p = 0.006), were less likely to present erythema (p = 0.028), and had higher serum C3 (p = 0.007) and incidence of infection within 1 year of their diagnosis (p = 0.035) than participants without MS. CONCLUSION: MS and its components hyperglycemia and overweight were found to be independently associated with BP. Therefore, clinicians should screen for MS in patients with BP, especially if they are older, present less erythema, or have a high serum C3.
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spelling pubmed-95770672022-10-19 Relationship between bullous pemphigoid and metabolic syndrome: a 12-year case–control study conducted in China Zhang, Bingjie Chen, Xinyi Liu, Yangchun Chen, Fangyuan Yang, Nan Li, Li Ther Adv Chronic Dis Original Research BACKGROUND: Hypertension, diabetes, dyslipidemia, and obesity are prevalent in patients with bullous pemphigoid (BP) and are all components of metabolic syndrome (MS). However, the prevalence of MS in patients with BP is unknown. We aimed to evaluate the relationship between MS and BP and to define the clinical and laboratory characteristics of patients with both conditions. METHODS: This retrospective case–control study was conducted for 12 years at Peking Union Medical College (162 with BP and 162 age and sex-matched controls). The components of MS were analyzed and logistic regression was used to identify independent risk factors for BP. In addition, the clinical and laboratory characteristics of patients with BP ± MS were compared. RESULTS: The prevalence of MS in patients with BP was 35.2% and that in controls was 14.8% (p < 0.001). After adjustment for sex and age, multivariate analysis demonstrated a positive correlation between BP and MS [odds ratio (OR) 2.490, 95% confidence interval (CI) 1.040–5.963], diabetes (OR 1.870, 95% CI 1.029–3.396), and overweight or obesity (OR 1.807, 95% CI 1.026–3.182). In the BP group, participants with MS were older (p = 0.006), were less likely to present erythema (p = 0.028), and had higher serum C3 (p = 0.007) and incidence of infection within 1 year of their diagnosis (p = 0.035) than participants without MS. CONCLUSION: MS and its components hyperglycemia and overweight were found to be independently associated with BP. Therefore, clinicians should screen for MS in patients with BP, especially if they are older, present less erythema, or have a high serum C3. SAGE Publications 2022-10-15 /pmc/articles/PMC9577067/ /pubmed/36267486 http://dx.doi.org/10.1177/20406223221130707 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Zhang, Bingjie
Chen, Xinyi
Liu, Yangchun
Chen, Fangyuan
Yang, Nan
Li, Li
Relationship between bullous pemphigoid and metabolic syndrome: a 12-year case–control study conducted in China
title Relationship between bullous pemphigoid and metabolic syndrome: a 12-year case–control study conducted in China
title_full Relationship between bullous pemphigoid and metabolic syndrome: a 12-year case–control study conducted in China
title_fullStr Relationship between bullous pemphigoid and metabolic syndrome: a 12-year case–control study conducted in China
title_full_unstemmed Relationship between bullous pemphigoid and metabolic syndrome: a 12-year case–control study conducted in China
title_short Relationship between bullous pemphigoid and metabolic syndrome: a 12-year case–control study conducted in China
title_sort relationship between bullous pemphigoid and metabolic syndrome: a 12-year case–control study conducted in china
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577067/
https://www.ncbi.nlm.nih.gov/pubmed/36267486
http://dx.doi.org/10.1177/20406223221130707
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