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GAPDH in neuroblastoma: Functions in metabolism and survival

Neuroblastoma is a pediatric cancer of neural crest cells. It develops most frequently in nerve cells around the adrenal gland, although other locations are possible. Neuroblastomas rely on glycolysis as a source of energy and metabolites, and the enzymes that catalyze glycolysis are potential thera...

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Autores principales: Cornett, Kevin, Puderbaugh, Anna, Back, Olivia, Craven, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577191/
https://www.ncbi.nlm.nih.gov/pubmed/36267982
http://dx.doi.org/10.3389/fonc.2022.979683
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author Cornett, Kevin
Puderbaugh, Anna
Back, Olivia
Craven, Rolf
author_facet Cornett, Kevin
Puderbaugh, Anna
Back, Olivia
Craven, Rolf
author_sort Cornett, Kevin
collection PubMed
description Neuroblastoma is a pediatric cancer of neural crest cells. It develops most frequently in nerve cells around the adrenal gland, although other locations are possible. Neuroblastomas rely on glycolysis as a source of energy and metabolites, and the enzymes that catalyze glycolysis are potential therapeutic targets for neuroblastoma. Furthermore, glycolysis provides a protective function against DNA damage, and there is evidence that glycolysis inhibitors may improve outcomes from other cancer treatments. This mini-review will focus on glyceraldehyde 3-phosphate dehydrogenase (GAPDH), one of the central enzymes in glycolysis. GAPDH has a key role in metabolism, catalyzing the sixth step in glycolysis and generating NADH. GAPDH also has a surprisingly diverse number of localizations, including the nucleus, where it performs multiple functions, and the plasma membrane. One membrane-associated function of GAPDH is stimulating glucose uptake, consistent with a role for GAPDH in energy and metabolite production. The plasma membrane localization of GAPDH and its role in glucose uptake have been verified in neuroblastoma. Membrane-associated GAPDH also participates in iron uptake, although this has not been tested in neuroblastoma. Finally, GAPDH activates autophagy through a nuclear complex with Sirtuin. This review will discuss these activities and their potential role in cancer metabolism, treatment and drug resistance.
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spelling pubmed-95771912022-10-19 GAPDH in neuroblastoma: Functions in metabolism and survival Cornett, Kevin Puderbaugh, Anna Back, Olivia Craven, Rolf Front Oncol Oncology Neuroblastoma is a pediatric cancer of neural crest cells. It develops most frequently in nerve cells around the adrenal gland, although other locations are possible. Neuroblastomas rely on glycolysis as a source of energy and metabolites, and the enzymes that catalyze glycolysis are potential therapeutic targets for neuroblastoma. Furthermore, glycolysis provides a protective function against DNA damage, and there is evidence that glycolysis inhibitors may improve outcomes from other cancer treatments. This mini-review will focus on glyceraldehyde 3-phosphate dehydrogenase (GAPDH), one of the central enzymes in glycolysis. GAPDH has a key role in metabolism, catalyzing the sixth step in glycolysis and generating NADH. GAPDH also has a surprisingly diverse number of localizations, including the nucleus, where it performs multiple functions, and the plasma membrane. One membrane-associated function of GAPDH is stimulating glucose uptake, consistent with a role for GAPDH in energy and metabolite production. The plasma membrane localization of GAPDH and its role in glucose uptake have been verified in neuroblastoma. Membrane-associated GAPDH also participates in iron uptake, although this has not been tested in neuroblastoma. Finally, GAPDH activates autophagy through a nuclear complex with Sirtuin. This review will discuss these activities and their potential role in cancer metabolism, treatment and drug resistance. Frontiers Media S.A. 2022-10-04 /pmc/articles/PMC9577191/ /pubmed/36267982 http://dx.doi.org/10.3389/fonc.2022.979683 Text en Copyright © 2022 Cornett, Puderbaugh, Back and Craven https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Cornett, Kevin
Puderbaugh, Anna
Back, Olivia
Craven, Rolf
GAPDH in neuroblastoma: Functions in metabolism and survival
title GAPDH in neuroblastoma: Functions in metabolism and survival
title_full GAPDH in neuroblastoma: Functions in metabolism and survival
title_fullStr GAPDH in neuroblastoma: Functions in metabolism and survival
title_full_unstemmed GAPDH in neuroblastoma: Functions in metabolism and survival
title_short GAPDH in neuroblastoma: Functions in metabolism and survival
title_sort gapdh in neuroblastoma: functions in metabolism and survival
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577191/
https://www.ncbi.nlm.nih.gov/pubmed/36267982
http://dx.doi.org/10.3389/fonc.2022.979683
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