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Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate

Glytrexate, developed by our team, as a novel multitarget folate antagonist, has inhibitory effects on a variety of cancer cell types, especially KB tumor cells (IC(50) 0.078 nM), and thus has antitumor drug development prospects. However, its pharmacokinetics and plasma protein binding properties r...

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Detalles Bibliográficos
Autores principales:	Xiang, Jiahong, Wu, Mengqi, Wang, Jianchao, Lin, Mengmeng, Sun, Mengmeng, Li, Xin, Xing, Ruijuan, Guo, Ran, Gu, Jianmin, Lyu, Tao, Wang, Lei, Shi, Xiaowei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577195/ https://www.ncbi.nlm.nih.gov/pubmed/36267288 http://dx.doi.org/10.3389/fphar.2022.1001308

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