Prior respiratory syncytial virus infection reduces vaccine-mediated Th2-skewed immunity, but retains enhanced RSV F-specific CD8 T cell responses elicited by a Th1-skewing vaccine formulation

Respiratory syncytial virus (RSV) remains the most common cause of lower respiratory tract infections in children worldwide. Development of a vaccine has been hindered due the risk of enhanced respiratory disease (ERD) following natural RSV exposure and the young age (<6 months) at which children...

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Detalles Bibliográficos
Autores principales: Eichinger, Katherine M., Kosanovich, Jessica L., Perkins, Timothy N., Oury, Tim D., Petrovsky, Nikolai, Marshall, Christopher P., Yondola, Mark A., Empey, Kerry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577258/
https://www.ncbi.nlm.nih.gov/pubmed/36268035
http://dx.doi.org/10.3389/fimmu.2022.1025341

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