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Hexosamine pathway activation improves memory but does not extend lifespan in mice

Glucosamine feeding and genetic activation of the hexosamine biosynthetic pathway (HBP) have been linked to improved protein quality control and lifespan extension. However, as an energy sensor, the HBP has been implicated in tumor progression and diabetes. Given these opposing outcomes, it is imper...

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Detalles Bibliográficos
Autores principales: Allmeroth, Kira, Hartman, Matías D., Purrio, Martin, Mesaros, Andrea, Denzel, Martin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577955/
https://www.ncbi.nlm.nih.gov/pubmed/36124412
http://dx.doi.org/10.1111/acel.13711

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