Reduced endosomal microautophagy activity in aging associates with enhanced exocyst‐mediated protein secretion

Autophagy is essential for protein quality control and regulation of the functional proteome. Failure of autophagy pathways with age contributes to loss of proteostasis in aged organisms and accelerates the progression of age‐related diseases. In this work, we show that activity of endosomal microau...

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Detalles Bibliográficos
Autores principales: Krause, Gregory J., Diaz, Antonio, Jafari, Maryam, Khawaja, Rabia R., Agullo‐Pascual, Esperanza, Santiago‐Fernández, Olaya, Richards, Alicia L., Chen, Kuei‐Ho, Dmitriev, Phillip, Sun, Yan, See, Stephanie K., Abdelmohsen, Kotb, Mazan‐Mamczarz, Krystyna, Krogan, Nevan J., Gorospe, Myriam, Swaney, Danielle L., Sidoli, Simone, Bravo‐Cordero, Jose Javier, Kampmann, Martin, Cuervo, Ana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577956/
https://www.ncbi.nlm.nih.gov/pubmed/36116133
http://dx.doi.org/10.1111/acel.13713

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