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Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[n]urils

[Image: see text] Viruses are microscopic pathogens capable of causing disease and are responsible for a range of human mortalities and morbidities worldwide. They can be rendered harmless or destroyed with a range of antiviral chemical compounds. Cucurbit[n]urils (CB[n]s) are a family of macrocycle...

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Autores principales: Jones, Luke M., Super, Elana H., Batt, Lauren J., Gasbarri, Matteo, Coppola, Francesco, Bhebhe, Lorraine M., Cheesman, Benjamin T., Howe, Andrew M., Král, Petr, Coulston, Roger, Jones, Samuel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578052/
https://www.ncbi.nlm.nih.gov/pubmed/36062478
http://dx.doi.org/10.1021/acsinfecdis.2c00186
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author Jones, Luke M.
Super, Elana H.
Batt, Lauren J.
Gasbarri, Matteo
Coppola, Francesco
Bhebhe, Lorraine M.
Cheesman, Benjamin T.
Howe, Andrew M.
Král, Petr
Coulston, Roger
Jones, Samuel T.
author_facet Jones, Luke M.
Super, Elana H.
Batt, Lauren J.
Gasbarri, Matteo
Coppola, Francesco
Bhebhe, Lorraine M.
Cheesman, Benjamin T.
Howe, Andrew M.
Král, Petr
Coulston, Roger
Jones, Samuel T.
author_sort Jones, Luke M.
collection PubMed
description [Image: see text] Viruses are microscopic pathogens capable of causing disease and are responsible for a range of human mortalities and morbidities worldwide. They can be rendered harmless or destroyed with a range of antiviral chemical compounds. Cucurbit[n]urils (CB[n]s) are a family of macrocycle chemical compounds existing as a range of homologues; due to their structure, they can bind to biological materials, acting as supramolecular “hosts” to “guests”, such as amino acids. Due to the increasing need for a nontoxic antiviral compound, we investigated whether cucurbit[n]urils could act in an antiviral manner. We have found that certain cucurbit[n]uril homologues do indeed have an antiviral effect against a range of viruses, including herpes simplex virus 2 (HSV-2), respiratory syncytial virus (RSV) and SARS-CoV-2. In particular, we demonstrate that CB[7] is the active homologue of CB[n], having an antiviral effect against enveloped and nonenveloped species. High levels of efficacy were observed with 5 min contact times across different viruses. We also demonstrate that CB[7] acts with an extracellular virucidal mode of action via host–guest supramolecular interactions between viral surface proteins and the CB[n] cavity, rather than via cell internalization or a virustatic mechanism. This finding demonstrates that CB[7] acts as a supramolecular virucidal antiviral (a mechanism distinct from other current extracellular antivirals), demonstrating the potential of supramolecular interactions for future antiviral disinfectants.
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spelling pubmed-95780522022-10-19 Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[n]urils Jones, Luke M. Super, Elana H. Batt, Lauren J. Gasbarri, Matteo Coppola, Francesco Bhebhe, Lorraine M. Cheesman, Benjamin T. Howe, Andrew M. Král, Petr Coulston, Roger Jones, Samuel T. ACS Infect Dis [Image: see text] Viruses are microscopic pathogens capable of causing disease and are responsible for a range of human mortalities and morbidities worldwide. They can be rendered harmless or destroyed with a range of antiviral chemical compounds. Cucurbit[n]urils (CB[n]s) are a family of macrocycle chemical compounds existing as a range of homologues; due to their structure, they can bind to biological materials, acting as supramolecular “hosts” to “guests”, such as amino acids. Due to the increasing need for a nontoxic antiviral compound, we investigated whether cucurbit[n]urils could act in an antiviral manner. We have found that certain cucurbit[n]uril homologues do indeed have an antiviral effect against a range of viruses, including herpes simplex virus 2 (HSV-2), respiratory syncytial virus (RSV) and SARS-CoV-2. In particular, we demonstrate that CB[7] is the active homologue of CB[n], having an antiviral effect against enveloped and nonenveloped species. High levels of efficacy were observed with 5 min contact times across different viruses. We also demonstrate that CB[7] acts with an extracellular virucidal mode of action via host–guest supramolecular interactions between viral surface proteins and the CB[n] cavity, rather than via cell internalization or a virustatic mechanism. This finding demonstrates that CB[7] acts as a supramolecular virucidal antiviral (a mechanism distinct from other current extracellular antivirals), demonstrating the potential of supramolecular interactions for future antiviral disinfectants. American Chemical Society 2022-09-05 2022-10-14 /pmc/articles/PMC9578052/ /pubmed/36062478 http://dx.doi.org/10.1021/acsinfecdis.2c00186 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Jones, Luke M.
Super, Elana H.
Batt, Lauren J.
Gasbarri, Matteo
Coppola, Francesco
Bhebhe, Lorraine M.
Cheesman, Benjamin T.
Howe, Andrew M.
Král, Petr
Coulston, Roger
Jones, Samuel T.
Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[n]urils
title Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[n]urils
title_full Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[n]urils
title_fullStr Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[n]urils
title_full_unstemmed Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[n]urils
title_short Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[n]urils
title_sort broad-spectrum extracellular antiviral properties of cucurbit[n]urils
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578052/
https://www.ncbi.nlm.nih.gov/pubmed/36062478
http://dx.doi.org/10.1021/acsinfecdis.2c00186
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