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11β-HSD1 contributes to age-related metabolic decline in male mice

The aged phenotype shares several metabolic similarities with that of circulatory glucocorticoid excess (Cushing’s syndrome), including type 2 diabetes, obesity, hypertension, and myopathy. We hypothesise that local tissue generation of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1 (11β...

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Detalles Bibliográficos
Autores principales:	Morgan, Stuart A, Gathercole, Laura L, Hassan-Smith, Zaki K, Tomlinson, Jeremy, Stewart, Paul M, Lavery, Gareth G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578088/ https://www.ncbi.nlm.nih.gov/pubmed/36205523 http://dx.doi.org/10.1530/JOE-22-0169

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