Sending out an SOS - the bacterial DNA damage response

The term “SOS response” was first coined by Radman in 1974, in an intellectual effort to put together the data suggestive of a concerted gene expression program in cells undergoing DNA damage. A large amount of information about this cellular response has been collected over the following decades. I...

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Autores principales: Lima-Noronha, Marco A., Fonseca, Douglas L. H., Oliveira, Renatta S., Freitas, Rúbia R., Park, Jung H., Galhardo, Rodrigo S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2022
Materias:
Young Brazilian Geneticists - Special Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578287/
https://www.ncbi.nlm.nih.gov/pubmed/36288458
http://dx.doi.org/10.1590/1678-4685-GMB-2022-0107
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author Lima-Noronha, Marco A.
Fonseca, Douglas L. H.
Oliveira, Renatta S.
Freitas, Rúbia R.
Park, Jung H.
Galhardo, Rodrigo S.
author_facet Lima-Noronha, Marco A.
Fonseca, Douglas L. H.
Oliveira, Renatta S.
Freitas, Rúbia R.
Park, Jung H.
Galhardo, Rodrigo S.
author_sort Lima-Noronha, Marco A.
collection PubMed
description The term “SOS response” was first coined by Radman in 1974, in an intellectual effort to put together the data suggestive of a concerted gene expression program in cells undergoing DNA damage. A large amount of information about this cellular response has been collected over the following decades. In this review, we will focus on a few of the relevant aspects about the SOS response: its mechanism of control and the stressors which activate it, the diversity of regulated genes in different species, its role in mutagenesis and evolution including the development of antimicrobial resistance, and its relationship with mobile genetic elements.
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spelling pubmed-95782872022-10-26 Sending out an SOS - the bacterial DNA damage response Lima-Noronha, Marco A. Fonseca, Douglas L. H. Oliveira, Renatta S. Freitas, Rúbia R. Park, Jung H. Galhardo, Rodrigo S. Genet Mol Biol Young Brazilian Geneticists - Special Issue The term “SOS response” was first coined by Radman in 1974, in an intellectual effort to put together the data suggestive of a concerted gene expression program in cells undergoing DNA damage. A large amount of information about this cellular response has been collected over the following decades. In this review, we will focus on a few of the relevant aspects about the SOS response: its mechanism of control and the stressors which activate it, the diversity of regulated genes in different species, its role in mutagenesis and evolution including the development of antimicrobial resistance, and its relationship with mobile genetic elements. Sociedade Brasileira de Genética 2022-10-10 /pmc/articles/PMC9578287/ /pubmed/36288458 http://dx.doi.org/10.1590/1678-4685-GMB-2022-0107 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Young Brazilian Geneticists - Special Issue
Lima-Noronha, Marco A.
Fonseca, Douglas L. H.
Oliveira, Renatta S.
Freitas, Rúbia R.
Park, Jung H.
Galhardo, Rodrigo S.
Sending out an SOS - the bacterial DNA damage response
title Sending out an SOS - the bacterial DNA damage response
title_full Sending out an SOS - the bacterial DNA damage response
title_fullStr Sending out an SOS - the bacterial DNA damage response
title_full_unstemmed Sending out an SOS - the bacterial DNA damage response
title_short Sending out an SOS - the bacterial DNA damage response
title_sort sending out an sos - the bacterial dna damage response
topic Young Brazilian Geneticists - Special Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578287/
https://www.ncbi.nlm.nih.gov/pubmed/36288458
http://dx.doi.org/10.1590/1678-4685-GMB-2022-0107
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