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Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant
The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We de...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Author(s). Published by Elsevier Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578327/ https://www.ncbi.nlm.nih.gov/pubmed/36272413 http://dx.doi.org/10.1016/j.chom.2022.10.003 |
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| author | Saito, Akatsuki Tamura, Tomokazu Zahradnik, Jiri Deguchi, Sayaka Tabata, Koshiro Anraku, Yuki Kimura, Izumi Ito, Jumpei Yamasoba, Daichi Nasser, Hesham Toyoda, Mako Nagata, Kayoko Uriu, Keiya Kosugi, Yusuke Fujita, Shigeru Shofa, Maya Monira Begum, MST Shimizu, Ryo Oda, Yoshitaka Suzuki, Rigel Ito, Hayato Nao, Naganori Wang, Lei Tsuda, Masumi Yoshimatsu, Kumiko Kuramochi, Jin Kita, Shunsuke Sasaki-Tabata, Kaori Fukuhara, Hideo Maenaka, Katsumi Yamamoto, Yuki Nagamoto, Tetsuharu Asakura, Hiroyuki Nagashima, Mami Sadamasu, Kenji Yoshimura, Kazuhisa Ueno, Takamasa Schreiber, Gideon Takaori-Kondo, Akifumi Shirakawa, Kotaro Sawa, Hirofumi Irie, Takashi Hashiguchi, Takao Takayama, Kazuo Matsuno, Keita Tanaka, Shinya Ikeda, Terumasa Fukuhara, Takasuke Sato, Kei |
| author_facet | Saito, Akatsuki Tamura, Tomokazu Zahradnik, Jiri Deguchi, Sayaka Tabata, Koshiro Anraku, Yuki Kimura, Izumi Ito, Jumpei Yamasoba, Daichi Nasser, Hesham Toyoda, Mako Nagata, Kayoko Uriu, Keiya Kosugi, Yusuke Fujita, Shigeru Shofa, Maya Monira Begum, MST Shimizu, Ryo Oda, Yoshitaka Suzuki, Rigel Ito, Hayato Nao, Naganori Wang, Lei Tsuda, Masumi Yoshimatsu, Kumiko Kuramochi, Jin Kita, Shunsuke Sasaki-Tabata, Kaori Fukuhara, Hideo Maenaka, Katsumi Yamamoto, Yuki Nagamoto, Tetsuharu Asakura, Hiroyuki Nagashima, Mami Sadamasu, Kenji Yoshimura, Kazuhisa Ueno, Takamasa Schreiber, Gideon Takaori-Kondo, Akifumi Shirakawa, Kotaro Sawa, Hirofumi Irie, Takashi Hashiguchi, Takao Takayama, Kazuo Matsuno, Keita Tanaka, Shinya Ikeda, Terumasa Fukuhara, Takasuke Sato, Kei |
| author_sort | Saito, Akatsuki |
| collection | PubMed |
| description | The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency, but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5. |
| format | Online Article Text |
| id | pubmed-9578327 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | The Author(s). Published by Elsevier Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-95783272022-10-18 Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant Saito, Akatsuki Tamura, Tomokazu Zahradnik, Jiri Deguchi, Sayaka Tabata, Koshiro Anraku, Yuki Kimura, Izumi Ito, Jumpei Yamasoba, Daichi Nasser, Hesham Toyoda, Mako Nagata, Kayoko Uriu, Keiya Kosugi, Yusuke Fujita, Shigeru Shofa, Maya Monira Begum, MST Shimizu, Ryo Oda, Yoshitaka Suzuki, Rigel Ito, Hayato Nao, Naganori Wang, Lei Tsuda, Masumi Yoshimatsu, Kumiko Kuramochi, Jin Kita, Shunsuke Sasaki-Tabata, Kaori Fukuhara, Hideo Maenaka, Katsumi Yamamoto, Yuki Nagamoto, Tetsuharu Asakura, Hiroyuki Nagashima, Mami Sadamasu, Kenji Yoshimura, Kazuhisa Ueno, Takamasa Schreiber, Gideon Takaori-Kondo, Akifumi Shirakawa, Kotaro Sawa, Hirofumi Irie, Takashi Hashiguchi, Takao Takayama, Kazuo Matsuno, Keita Tanaka, Shinya Ikeda, Terumasa Fukuhara, Takasuke Sato, Kei Cell Host Microbe Article The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency, but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5. The Author(s). Published by Elsevier Inc. 2022-11-09 2022-10-18 /pmc/articles/PMC9578327/ /pubmed/36272413 http://dx.doi.org/10.1016/j.chom.2022.10.003 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Saito, Akatsuki Tamura, Tomokazu Zahradnik, Jiri Deguchi, Sayaka Tabata, Koshiro Anraku, Yuki Kimura, Izumi Ito, Jumpei Yamasoba, Daichi Nasser, Hesham Toyoda, Mako Nagata, Kayoko Uriu, Keiya Kosugi, Yusuke Fujita, Shigeru Shofa, Maya Monira Begum, MST Shimizu, Ryo Oda, Yoshitaka Suzuki, Rigel Ito, Hayato Nao, Naganori Wang, Lei Tsuda, Masumi Yoshimatsu, Kumiko Kuramochi, Jin Kita, Shunsuke Sasaki-Tabata, Kaori Fukuhara, Hideo Maenaka, Katsumi Yamamoto, Yuki Nagamoto, Tetsuharu Asakura, Hiroyuki Nagashima, Mami Sadamasu, Kenji Yoshimura, Kazuhisa Ueno, Takamasa Schreiber, Gideon Takaori-Kondo, Akifumi Shirakawa, Kotaro Sawa, Hirofumi Irie, Takashi Hashiguchi, Takao Takayama, Kazuo Matsuno, Keita Tanaka, Shinya Ikeda, Terumasa Fukuhara, Takasuke Sato, Kei Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant |
| title | Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant |
| title_full | Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant |
| title_fullStr | Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant |
| title_full_unstemmed | Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant |
| title_short | Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant |
| title_sort | virological characteristics of the sars-cov-2 omicron ba.2.75 variant |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578327/ https://www.ncbi.nlm.nih.gov/pubmed/36272413 http://dx.doi.org/10.1016/j.chom.2022.10.003 |
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