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Targeted memory reactivation during sleep can induce forgetting of overlapping memories

Memory reactivation during sleep can shape new memories into a long-term form. Reactivation of memories can be induced via the delivery of auditory cues during sleep. Although this targeted memory reactivation (TMR) approach can strengthen newly acquired memories, research has tended to focus on sin...

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Autores principales: Joensen, Bárður H., Harrington, Marcus O., Berens, Sam C., Cairney, Scott A., Gaskell, M. Gareth, Horner, Aidan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578373/
https://www.ncbi.nlm.nih.gov/pubmed/36253007
http://dx.doi.org/10.1101/lm.053594.122
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author Joensen, Bárður H.
Harrington, Marcus O.
Berens, Sam C.
Cairney, Scott A.
Gaskell, M. Gareth
Horner, Aidan J.
author_facet Joensen, Bárður H.
Harrington, Marcus O.
Berens, Sam C.
Cairney, Scott A.
Gaskell, M. Gareth
Horner, Aidan J.
author_sort Joensen, Bárður H.
collection PubMed
description Memory reactivation during sleep can shape new memories into a long-term form. Reactivation of memories can be induced via the delivery of auditory cues during sleep. Although this targeted memory reactivation (TMR) approach can strengthen newly acquired memories, research has tended to focus on single associative memories. It is less clear how TMR affects retention for overlapping associative memories. This is critical, given that repeated retrieval of overlapping associations during wake can lead to forgetting, a phenomenon known as retrieval-induced forgetting (RIF). We asked whether a similar pattern of forgetting occurs when TMR is used to cue reactivation of overlapping pairwise associations during sleep. Participants learned overlapping pairs—learned separately, interleaved with other unrelated pairs. During sleep, we cued a subset of overlapping pairs using TMR. While TMR increased retention for the first encoded pairs, memory decreased for the second encoded pairs. This pattern of retention was only present for pairs not tested prior to sleep. The results suggest that TMR can lead to forgetting, an effect similar to RIF during wake. However, this effect did not extend to memories that had been strengthened via retrieval prior to sleep. We therefore provide evidence for a reactivation-induced forgetting effect during sleep.
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spelling pubmed-95783732022-11-01 Targeted memory reactivation during sleep can induce forgetting of overlapping memories Joensen, Bárður H. Harrington, Marcus O. Berens, Sam C. Cairney, Scott A. Gaskell, M. Gareth Horner, Aidan J. Learn Mem Research Memory reactivation during sleep can shape new memories into a long-term form. Reactivation of memories can be induced via the delivery of auditory cues during sleep. Although this targeted memory reactivation (TMR) approach can strengthen newly acquired memories, research has tended to focus on single associative memories. It is less clear how TMR affects retention for overlapping associative memories. This is critical, given that repeated retrieval of overlapping associations during wake can lead to forgetting, a phenomenon known as retrieval-induced forgetting (RIF). We asked whether a similar pattern of forgetting occurs when TMR is used to cue reactivation of overlapping pairwise associations during sleep. Participants learned overlapping pairs—learned separately, interleaved with other unrelated pairs. During sleep, we cued a subset of overlapping pairs using TMR. While TMR increased retention for the first encoded pairs, memory decreased for the second encoded pairs. This pattern of retention was only present for pairs not tested prior to sleep. The results suggest that TMR can lead to forgetting, an effect similar to RIF during wake. However, this effect did not extend to memories that had been strengthened via retrieval prior to sleep. We therefore provide evidence for a reactivation-induced forgetting effect during sleep. Cold Spring Harbor Laboratory Press 2022-11 /pmc/articles/PMC9578373/ /pubmed/36253007 http://dx.doi.org/10.1101/lm.053594.122 Text en © 2022 Joensen et al.; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by/4.0/This article, published in Learning & Memory, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Joensen, Bárður H.
Harrington, Marcus O.
Berens, Sam C.
Cairney, Scott A.
Gaskell, M. Gareth
Horner, Aidan J.
Targeted memory reactivation during sleep can induce forgetting of overlapping memories
title Targeted memory reactivation during sleep can induce forgetting of overlapping memories
title_full Targeted memory reactivation during sleep can induce forgetting of overlapping memories
title_fullStr Targeted memory reactivation during sleep can induce forgetting of overlapping memories
title_full_unstemmed Targeted memory reactivation during sleep can induce forgetting of overlapping memories
title_short Targeted memory reactivation during sleep can induce forgetting of overlapping memories
title_sort targeted memory reactivation during sleep can induce forgetting of overlapping memories
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578373/
https://www.ncbi.nlm.nih.gov/pubmed/36253007
http://dx.doi.org/10.1101/lm.053594.122
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