Dose-sparing effect of two adjuvant formulations with a pandemic influenza A/H7N9 vaccine: A randomized, double-blind, placebo-controlled, phase 1 clinical trial

The emergence of potentially pandemic viruses has resulted in preparedness efforts to develop candidate vaccines and adjuvant formulations. We evaluated the dose-sparing effect and safety of two distinct squalene-based oil-in-water adjuvant emulsion formulations (IB160 and SE) with influenza A/H7N9...

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Detalles Bibliográficos
Autores principales: Vanni, Tazio, Thomé, Beatriz C., Sparrow, Erin, Friede, Martin, Fox, Christopher B., Beckmann, Anna Marie, Huynh, Chuong, Mondini, Gabriella, Silveira, Daniela H., Viscondi, Juliana Y. K., Braga, Patrícia Emilia, da Silva, Anderson, Salomão, Maria da Graça, Piorelli, Roberta O., Santos, Joane P., Gattás, Vera Lúcia, Lucchesi, Maria Beatriz B., de Oliveira, Mayra M. M., Koike, Marcelo E., Kallas, Esper G., Campos, Lucia M. A., Coelho, Eduardo B., Siqueira, Marilda A. M., Garcia, Cristiana C., Miranda, Milene Dias, Paiva, Terezinha M., Timenetsky, Maria do Carmo S. T., Adami, Eduardo A., Akamatsu, Milena A., Ho, Paulo Lee, Precioso, Alexander R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578608/
https://www.ncbi.nlm.nih.gov/pubmed/36256646
http://dx.doi.org/10.1371/journal.pone.0274943

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