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Equine echocardiography: Can dobutamine infusion correct alterations due to sedation with alpha-2 agonists?

For the echocardiographic examination horses should not be sedated unless absolutely necessary because this alters cardiac dimensions and indices of function. However, some horses do not tolerate the echocardiographic procedure and require sedation to conduct the examination safely and obtain good q...

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Autores principales: Vitale, Valentina, Vezzosi, Tommaso, Di Franco, Chiara, Briganti, Angela, Tognetti, Rosalba, Conte, Giuseppe, Bucchioni, Elena, Sgorbini, Micaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578622/
https://www.ncbi.nlm.nih.gov/pubmed/36256667
http://dx.doi.org/10.1371/journal.pone.0276256
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author Vitale, Valentina
Vezzosi, Tommaso
Di Franco, Chiara
Briganti, Angela
Tognetti, Rosalba
Conte, Giuseppe
Bucchioni, Elena
Sgorbini, Micaela
author_facet Vitale, Valentina
Vezzosi, Tommaso
Di Franco, Chiara
Briganti, Angela
Tognetti, Rosalba
Conte, Giuseppe
Bucchioni, Elena
Sgorbini, Micaela
author_sort Vitale, Valentina
collection PubMed
description For the echocardiographic examination horses should not be sedated unless absolutely necessary because this alters cardiac dimensions and indices of function. However, some horses do not tolerate the echocardiographic procedure and require sedation to conduct the examination safely and obtain good quality images. The objective of this study was to evaluate whether the concurrent infusion of dobutamine in horses sedated with romifidine counteracts the cardiovascular changes observed with sedation alone. Twelve healthy untrained Standardbred mares were used. Three echocardiographic examinations were performed on the same day for each subject: a) without any treatment under resting conditions (WT); b) under sedation with romifidine administered intravenously (RT); c) under sedation with romifidine and concurrent intravenous infusion with dobutamine (RDT). A three-hour washout period was observed between each examination and the order of the examinations was randomly decided by rolling a dice. The measurements on the images recorded were performed offline at the end of the study protocol and at this point the operator was blinded to the horse and treatment administered. Left ventricular internal diameter (LVID) in diastole, left ventricular free wall (LVFW) in systole, and fractional shortening (FS) were higher in the WT group compared with the other two groups. No differences in the other M-mode and B-mode values were observed. A continuous rate infusion of dobutamine did not counteract the alterations caused by sedation and led to similar echocardiographic measurements to those obtained after romifidine administration.
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spelling pubmed-95786222022-10-19 Equine echocardiography: Can dobutamine infusion correct alterations due to sedation with alpha-2 agonists? Vitale, Valentina Vezzosi, Tommaso Di Franco, Chiara Briganti, Angela Tognetti, Rosalba Conte, Giuseppe Bucchioni, Elena Sgorbini, Micaela PLoS One Research Article For the echocardiographic examination horses should not be sedated unless absolutely necessary because this alters cardiac dimensions and indices of function. However, some horses do not tolerate the echocardiographic procedure and require sedation to conduct the examination safely and obtain good quality images. The objective of this study was to evaluate whether the concurrent infusion of dobutamine in horses sedated with romifidine counteracts the cardiovascular changes observed with sedation alone. Twelve healthy untrained Standardbred mares were used. Three echocardiographic examinations were performed on the same day for each subject: a) without any treatment under resting conditions (WT); b) under sedation with romifidine administered intravenously (RT); c) under sedation with romifidine and concurrent intravenous infusion with dobutamine (RDT). A three-hour washout period was observed between each examination and the order of the examinations was randomly decided by rolling a dice. The measurements on the images recorded were performed offline at the end of the study protocol and at this point the operator was blinded to the horse and treatment administered. Left ventricular internal diameter (LVID) in diastole, left ventricular free wall (LVFW) in systole, and fractional shortening (FS) were higher in the WT group compared with the other two groups. No differences in the other M-mode and B-mode values were observed. A continuous rate infusion of dobutamine did not counteract the alterations caused by sedation and led to similar echocardiographic measurements to those obtained after romifidine administration. Public Library of Science 2022-10-18 /pmc/articles/PMC9578622/ /pubmed/36256667 http://dx.doi.org/10.1371/journal.pone.0276256 Text en © 2022 Vitale et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Vitale, Valentina
Vezzosi, Tommaso
Di Franco, Chiara
Briganti, Angela
Tognetti, Rosalba
Conte, Giuseppe
Bucchioni, Elena
Sgorbini, Micaela
Equine echocardiography: Can dobutamine infusion correct alterations due to sedation with alpha-2 agonists?
title Equine echocardiography: Can dobutamine infusion correct alterations due to sedation with alpha-2 agonists?
title_full Equine echocardiography: Can dobutamine infusion correct alterations due to sedation with alpha-2 agonists?
title_fullStr Equine echocardiography: Can dobutamine infusion correct alterations due to sedation with alpha-2 agonists?
title_full_unstemmed Equine echocardiography: Can dobutamine infusion correct alterations due to sedation with alpha-2 agonists?
title_short Equine echocardiography: Can dobutamine infusion correct alterations due to sedation with alpha-2 agonists?
title_sort equine echocardiography: can dobutamine infusion correct alterations due to sedation with alpha-2 agonists?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578622/
https://www.ncbi.nlm.nih.gov/pubmed/36256667
http://dx.doi.org/10.1371/journal.pone.0276256
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