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Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids

The cellular microenvironment, together with intrinsic regulators, shapes stem cell identity and differentiation capacity. Mammalian early embryos are exposed to hypoxia in vivo and appear to benefit from hypoxic culture in vitro. Yet, how hypoxia influences stem cell transcriptional networks and li...

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Detalles Bibliográficos
Autores principales:	López-Anguita, Natalia, Gassaloglu, Seher Ipek, Stötzel, Maximilian, Bolondi, Adriano, Conkar, Deniz, Typou, Marina, Buschow, René, Veenvliet, Jesse V., Bulut-Karslioglu, Aydan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2022
Materias:	Stem Cells and Regeneration
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578691/ https://www.ncbi.nlm.nih.gov/pubmed/36102628 http://dx.doi.org/10.1242/dev.200679

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