Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis

Chromatin instability and protein homeostasis (proteostasis) stress are two well-established hallmarks of aging, which have been considered largely independent of each other. Using microfluidics and single-cell imaging approaches, we observed that, during the replicative aging of Saccharomyces cerev...

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Detalles Bibliográficos
Autores principales: Paxman, Julie, Zhou, Zhen, O'Laughlin, Richard, Liu, Yuting, Li, Yang, Tian, Wanying, Su, Hetian, Jiang, Yanfei, Holness, Shayna E, Stasiowski, Elizabeth, Tsimring, Lev S, Pillus, Lorraine, Hasty, Jeff, Hao, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578700/
https://www.ncbi.nlm.nih.gov/pubmed/36194205
http://dx.doi.org/10.7554/eLife.75978

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